LitCovid-sentences  

PMC:7247521 / 40380-47856 JSONTXT 13 Projects

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Id Subject Object Predicate Lexical cue
T309 0-13 Sentence denotes 4 Discussion
T310 14-104 Sentence denotes Novel coronavirus (2019-nCov) infection is characterized by lung and immune system damage.
T311 105-226 Sentence denotes Severe infection can lead to acute respiratory distress syndrome (ARDS) and septicemia, and eventually lead to death [2].
T312 227-311 Sentence denotes In addition, a number of patients presented multi-organ damage and dysfunction [28].
T313 312-394 Sentence denotes However, there are no specific drugs or vaccine for the treatment of the COVID-19.
T314 395-517 Sentence denotes This reason may partly be that a single targeted drug cannot cure a complex disease with complex biological networks [29].
T315 518-739 Sentence denotes Despite the lack of strong evidence-based medicine, TCM has a good potential to complement the medical service for COVID-19, including reverting radiological changes, and shortening fever duration and hospital stay. [30].
T316 740-885 Sentence denotes It is observed that the total effective rate of QFPD in the treatment of pneumonia patients infected by novel coronavirus is more than 90 % [31].
T317 886-1077 Sentence denotes Therefore, we explored the mechanism of QFPD against COVID-19 by systems pharmacology, and provided a combination strategy to explore the functional units in QFPD from a holistic perspective.
T318 1078-1196 Sentence denotes To our knowledge, this is the first study to explore the mechanisms of QFPD for COVID based on intra-functional units.
T319 1197-1541 Sentence denotes In this study, GO enrichment analysis showed that the common GO terms of MSXG, SGMH, XCH, WLS and Others targets were significant enriched in oxidoreductase activity, lipid metabolic process, lipid binding, small molecule metabolic process, and homeostatic process etc., suggesting QFPD may exert anti-viral activity through metabolic function.
T320 1542-1758 Sentence denotes In agreement with these results, a recent research has found that lipid metabolic reprograming plays an important role in virus replication, which may be an appealing and applicable target for antiviral therapy [32].
T321 1759-1991 Sentence denotes KEGG analysis showed that in addition to lipid metabolism-related pathways, endocrine system pathways were also significantly enriched in more than four formulae, including PPAR signaling pathway and adipocytokine signaling pathway.
T322 1992-2224 Sentence denotes A recent study has showed that the host can exert anti-inflammatory functions to inhibit excessive inflammatory damage through PPAR signaling pathway after H1N1 infection, thus keeping homeostasis of metabolism and development [33].
T323 2225-2530 Sentence denotes In addition, other common terms were significant enriched in more than two formulae, such as immune system process, endoplasmic reticulum, cell-cell signaling, calcium signaling pathway, vascular smooth muscle contraction, inflammatory mediator regulation of TRP channels, cardiac muscle contraction, etc.
T324 2531-2733 Sentence denotes Therefore, the multi-pathway and multi-target results of our intra functional unit of QFPD not only showed a new useful method for studying TCM, but may demonstrate the rationality of TCM compatibility.
T325 2734-2797 Sentence denotes Moreover, TCMATCOV platform was used to validate these results.
T326 2798-3200 Sentence denotes Interestingly, all the five FUs of QFPD showed higher disturbance score than negative control (BXTM), indicating that MSXG, SGMH, XCH, WLS and Others may protect COVID-19 independently, and target 8 specifically expressed drug-attacked nodes (Cdc20, Ido1, Ifng, Il10, Il6, Ptger4, Spi1, Tnf) which were related to the bacterial and viral responses, cytokine, immune system, signaling transduction, etc.
T327 3201-3455 Sentence denotes Currently, a number of studies have showed that 2019-nCov can cause multiple organs dysfunction, including liver [34], pancreas [35], kidney [36], throat and rectum [37], which may be the reason that a wide distribution of ACE2 across these tissues [38].
T328 3456-3727 Sentence denotes In agreement with these results, we found that ACE2 was highly expressed in terminal ileum, testis, adipose visceral omentum, heart left ventricle, kidney cortex and thyroid, etc., and QFPD has only 15.33 % common targets with 2019-nCov, pneumonia and ACE2 related genes.
T329 3728-3837 Sentence denotes These results indicate that the effective treatment of QFPD for COVID-19 may be through a holistic treatment.
T330 3838-4120 Sentence denotes Moreover, TTD analysis further displayed that QFPD targets were significantly enriched in many COVID-19 related disease, such as chronic inflammatory diseases, asthma, inflammatory bowel disease, chronic obstructive pulmonary disease, intrahepatic cholestasis, chronic ileitis, etc.
T331 4121-4271 Sentence denotes It is known that ADMETox prediction is an important part in evaluating if a drug can be toxic or can be absorbed during drug development process [39].
T332 4272-4511 Sentence denotes In our study, ADMETox evaluation shows that 20 compounds passed the stringent lead-like criteria (250 ≤ MW≤350 & XLOGP ≤ 3.5 & Number of rotatable bonds≤7) [40] and in silico drug-likeness test, and showed high gastrointestinal absorption.
T333 4512-4689 Sentence denotes Moreover, predicted toxicity evaluation showed that the median lethal dose (LD50) of all these ingredients was above 1600 mg/kg, thus may suggesting safety and efficacy of QFPD.
T334 4690-5024 Sentence denotes Combined with molecular docking results, 4 specific ingredients (M3, S1, X2 and O2) and 5 common ingredients (MS1, MX16, SX1, WO1 and XO1) of QFPD might be promising leading compounds with good molecular docking score for 2019-nCov structure and non-structure proteins, revealing that QFPD treated COVID-19 by multi-component synergy.
T335 5025-5099 Sentence denotes However, these newly monomer components should provide a further research.
T336 5100-5214 Sentence denotes It has been reported that host cellular microRNAs (miRNAs) are involved in the regulation of virus infection [41].
T337 5215-5346 Sentence denotes A previous study discovered that significantly up-regulated MIR301 and down-regulated MIR183/130B were found in H1N1 patients [42].
T338 5347-5536 Sentence denotes Consistent with these results, we found that MIR183 and MIR130A/B/301 are related to four functional units of QFPD, indicating these microRNAs may exert anti−COVID-19 activity through QFPD.
T339 5537-5746 Sentence denotes In addition, CDKs have played a role in the efficient replication of various viruses, including human HIV-1, papillomaviruses, human cytomegalovirus (HCMV), herpes simplex virus (HSV) type 1 and HSV-2 [43,44].
T340 5747-5978 Sentence denotes In agreement with these results, we found that CDK7 was predicted to enriched in the five formulae, suggesting that QFPD may regulate replication of COVID-19 viruses via CDK7 mediated cell cycle and RNA polymerase II transcription.
T341 5979-6157 Sentence denotes Recently, a previous study showed that LXR known to regulate cholesterol homeostasis during inflammation were differentially regulated during H1N1 influenza virus infection [45].
T342 6158-6352 Sentence denotes Based on our results that LXR was associated with MSXG, SGMH, XCH, WLS targets, we speculated that QFPD can regulate metabolic and pro-inflammatory processes to counter COVID-19 virus infection.
T343 6353-6412 Sentence denotes In summary, QFPD is effective in the treatment of COVID-19.
T344 6413-6590 Sentence denotes However, some shortcomings in our study include lack of an in-depth study of predictive monomers and key targets and pathways, thus need further validation in vivo and in vitro.
T345 6591-6857 Sentence denotes And the TCMATCOV platform uses SARS disease network, which is different from the COVID-19 disease network, and COVID-19-related cytokines are related to severe COVID-19 disease, so the results of platform analysis more reflect the potential efficacy of severe stage.
T346 6858-7013 Sentence denotes Nevertheless, this study confirms that network pharmacology can help explore the mechanism of QFPD on the treatment of COVID-19 with time- and cost-saving.
T347 7014-7206 Sentence denotes Moreover, based on our new FUNP analysis, we reveal that QFPD treat COVID-19 by a holistic treatment and multi-component synergy, and are further demonstrated by formula perturbation analysis.
T348 7207-7358 Sentence denotes In addition, this study provides possible candidate monomers of QFPD and related miRNAs, kinases and TFs with potential therapeutic effect on COVID-19.
T349 7359-7476 Sentence denotes This will hopefully provide evidence and new insights for further researches on the treatment of COVID-19 using QFPD.