LitCovid-sentences  

PMC:7247521 / 2386-6979 JSONTXT 12 Projects

Annnotations TAB TSV DIC JSON TextAE

Id Subject Object Predicate Lexical cue
T20 0-15 Sentence denotes 1 Introduction
T21 16-129 Sentence denotes 2019-novel coronavirus (2019-nCov) outbreak took place in December 2019 and continues to spread around the world.
T22 130-243 Sentence denotes By April 3, 2020, more than 1 million patients have been diagnosed with corona virus disease 2019 (COVID-19) [1].
T23 244-459 Sentence denotes The virus has a long incubation period, is highly contagious, and is generally susceptible to all types of people, which has a huge negative impact on people's health, economic development, and social stability [2].
T24 460-551 Sentence denotes However, there is still a lack of effective clinical drugs or vaccine to control the virus.
T25 552-685 Sentence denotes Traditional Chinese medicine has a good effect on viral infectious pneumonia and has shown a certain effect in the treatment of SARS.
T26 686-1377 Sentence denotes On February 7, 2020, the China Health Commission and the Administration of Traditional Chinese Medicine jointly issued a notice recommending formula Qingfei Paidu decoction (QFPD, Herba Ephedrae, Radix Glycyrrhizae, Semen Armeniacae Amarum, Gypsum Fibrosum, Ramulus Cinnamomi, Rhizoma Alismatis, Polyporus Umbellatus, Rhizoma Atractylodis Macrocephalae, Poria, Radix Bupleuri, Radix Scutellariae, Rhizome Pinelliae Preparata, Rhizoma Zingiberis Recens, Radix Asteris, Flos Farfarae, Rhizoma Belamcandae, Herba Asari, Rhizoma Dioscoreae, Fructus Aurantii Immaturus, Pericarpium Citri Reticulatae, Herba Pogostemonis) for the treatment of COVID-19 according to clinical treatment and efficacy.
T27 1378-1634 Sentence denotes QFPD is a compound prescription in TCM including Ma Xing Shi Gan decoction (MSXG), She Gan Ma Huang decoction (SGMH), Xiao Chai Hu (XCH), and Wu Ling San (WLS), which was first discovered in the classic Treatise on Exogenous Febrile Disease (Shanghan Lun).
T28 1635-1881 Sentence denotes MXSG (Herba Ephedrae, Radix Glycyrrhizae, Semen Armeniacae Amarum, Gypsum Fibrosum) has been used for the treatment of the common cold, fever, and influenza virus infections via damaging the viral surface structure and inhibiting viral entry [3].
T29 1882-2146 Sentence denotes SGMH (Herba Ephedrae, Rhizome Pinelliae Preparata, Rhizoma Zingiberis Recens, Radix Asteris, Flos Farfarae, Rhizoma Belamcandae, Herba Asari) is a classical prescription for the treatment of flu-like symptoms, asthma, inflammation, tonsillitis and sore throat [4].
T30 2147-2332 Sentence denotes XCH (Radix Glycyrrhizae, Radix Bupleuri, Radix Scutellariae, Rhizome Pinelliae Preparata, Rhizoma Zingiberis Recens) possesses antiviral [5] and various anticarcinogenic properties [6].
T31 2333-2572 Sentence denotes WLS (Ramulus Cinnamomi, Rhizoma Alismatis, Polyporus Umbellatus, Rhizoma Atractylodis Macrocephalae, Poria), a famous Chinese prescription for nephritic syndrome, can improve kidney excretion function and inhibit inflammatory response [7].
T32 2573-2668 Sentence denotes These researches indicate that MXSG, SGMH, XCH and WLS may be functional units of formula QFPD.
T33 2669-2788 Sentence denotes Previous studies have focused on the mechanism of compound prescription based on a single traditional Chinese medicine.
T34 2789-2884 Sentence denotes However, it may not reflect functional compatibility mechanism of traditional Chinese medicine.
T35 2885-3062 Sentence denotes Therefore, it is worthy of comparing the similarities and differences of different QFPD functional units in the treatment of COVID-19, including MXSG, SGMH, XCH, WLS and Others.
T36 3063-3297 Sentence denotes QFPD contains a total of 21 traditional Chinese medicines, and it is difficult to elucidate the complex mechanism of QFPD on COVID-19 by traditional pharmacological methods due to the multi-components and multi-targets of the formula.
T37 3298-3455 Sentence denotes Network pharmacology, a new method in recent years, can integrate interactions of drugs, targets, pathways and diseases into a biological network system [8].
T38 3456-3727 Sentence denotes Therefore, more and more TCM researchers have begun to use network pharmacology to explore the material basis of TCM, and to reveal the overall comprehensive effects of multi-path, multi-component and multi-target of TCM prescription and its treatment of diseases [9,10].
T39 3728-3897 Sentence denotes More importantly, previous study reported that disease conditions can be more fragile than health systems against various perturbations for the un-optimized system [11].
T40 3898-4053 Sentence denotes So the formula may be more effective for COVID-19 disease via the stronger effects on the reduction of the robustness of the COVID-19 disease network [12].
T41 4054-4274 Sentence denotes In our study, since MSXG, SGMH, XCH and WLS have been independently used for the treatment of viral infectious pneumonia, this study firstly screened out major effective compounds from five functional units respectively.
T42 4275-4593 Sentence denotes Then we offered a new understanding of the functional units mechanism of QFPD against COVID-19 by a novel functional units of network pharmacology (FUNP) approach and formula perturbation analysis, and provided a combination strategy to explore mechanisms of inter-ingredients interactions from a holistic perspective.