| Id |
Subject |
Object |
Predicate |
Lexical cue |
| T161 |
0-308 |
Sentence |
denotes |
Fig. 8 CLQ-OH/ATM combination therapy at the molecular level. (a) ATM bound to the SARS-CoV-2 spike protein trimer. (b) Ganglioside dimer (two symmetrically arranged GM1 molecules in a typical chalice-like shape, just like the one observed in lipid raft simulations) bound to SARS-CoV-2 spike protein trimer. |
| T162 |
309-452 |
Sentence |
denotes |
Note that both ATM and gangliosides share the same binding region. (c) ATM prevents ganglioside binding to the SARS-CoV-2 spike protein trimer. |
| T163 |
453-620 |
Sentence |
denotes |
CLQ-OH, once bound to gangliosides (blue and orange surfaces), also prevents any interaction with the viral spike. (d) 4 CLQ-OH molecules bound to a ganglioside dimer. |
| T164 |
621-813 |
Sentence |
denotes |
Each GM1 molecule is blocked by two CLQ-OH molecules (blue and orange surfaces), which wrap around the saccharide part. (e) Detail of the 134-138 SARS-CoV-2 spike protein stretch bound to GM1. |
| T165 |
814-964 |
Sentence |
denotes |
Note that the ganglioside interacts with Q-134 and F-135, but not with D-138. (f) Detail of the 134-138 SARS-CoV-2 spike protein stretch bound to ATM. |
| T166 |
965-1042 |
Sentence |
denotes |
In this case, the binding site includes D-138 in addition to Q-134 and F-135. |
| T167 |
1043-1163 |
Sentence |
denotes |
Note that N-137, which interacts with both ATM and GM1, is not visible in these representations as it is located behind. |
