| Id |
Subject |
Object |
Predicate |
Lexical cue |
| T40 |
0-30 |
Sentence |
denotes |
3.1.1 Polybasic cleavage site |
| T41 |
31-202 |
Sentence |
denotes |
As evidenced by sequence analysis, there is a residue insertion formed of four amino acids (12 nucleotides) at the boundary between S1 and S2 subunits of the SARS-CoV 2 S. |
| T42 |
203-405 |
Sentence |
denotes |
It defines a polybasic furin cleavage site of RRAR for the human SARS-CoV 2 that was absent in human SARS-CoV, bat SARS-like CoVs, and pangolin SARS-like CoV while might be present in other species [3]. |
| T43 |
406-556 |
Sentence |
denotes |
After the introduction of mutation to the residue insertion and furin cleavage site, the S1/S2 cleavage of the SARS-CoV 2 S did not longer take place. |
| T44 |
557-667 |
Sentence |
denotes |
However, the SARS-CoV 2 S entry raised for VeroE6 cells and remained high in BHK cells that express human ACE. |
| T45 |
668-758 |
Sentence |
denotes |
Therefore, it seems that SARS-CoV2 transmissibility does not depend on the S1/S2 cleavage. |
| T46 |
759-884 |
Sentence |
denotes |
A polybasic cleavage site explains a virus that is highly-pathogenic for humans while it is low-pathogenic for other species. |
| T47 |
885-1033 |
Sentence |
denotes |
For example, using reverse genetic tools, an avian paramyxovirus type 7 (APMV-7) was developed by mutating the fusion (F) protein cleavage site [4]. |
| T48 |
1034-1146 |
Sentence |
denotes |
The constructed APMV-7 showed furin cleavage and increased replication and syncytium formation in cell cultures. |
| T49 |
1147-1211 |
Sentence |
denotes |
However, chicken exposed to the virus did not exhibit infection. |
