| Id |
Subject |
Object |
Predicate |
Lexical cue |
| T284 |
0-205 |
Sentence |
denotes |
This was also observed in the previous SARS-CoV-1 epidemic, where neutralizing titers were found to be significantly higher in deceased patients compared to patients who had recovered (Zhang et al., 2006). |
| T285 |
206-362 |
Sentence |
denotes |
This has led to concerns that antibody responses to these viruses may contribute to pulmonary pathology via antibody-dependent enhancement (ADE) (Figure 4). |
| T286 |
363-621 |
Sentence |
denotes |
This phenomenon is observed when non-neutralizing virus-specific IgG facilitate entry of virus particles into Fc-receptor (FcR) expressing cells, particularly macrophages and monocytes, leading to inflammatory activation of these cells (Taylor et al., 2015). |
| T287 |
622-822 |
Sentence |
denotes |
A study in SARS-CoV-1-infected rhesus macaques found that anti-S IgG contributed to severe acute lung injury (ALI) and massive accumulation of monocytes and macrophages in the lung (Liu et al., 2019). |
| T288 |
823-991 |
Sentence |
denotes |
Furthermore, serum containing anti-S Ig from SARS-CoV-1 patients enhanced the infection of SARS-CoV-1 in human monocyte-derived macrophages in vitro (Yip et al., 2014). |
| T289 |
992-1099 |
Sentence |
denotes |
ADE was also reported with a monoclonal antibody isolated from a patient with MERS-CoV (Wan et al., 2020c). |
| T290 |
1100-1337 |
Sentence |
denotes |
Somewhat reassuringly, there was no evidence of ADE mediated by sera from rats vaccinated with SARS-CoV-2 RBD in vitro (Quinlan et al., 2020) nor in macaques immunized with an inactivated SARS-CoV-2 vaccine candidate (Gao et al., 2020c). |
