LitCovid-sentences  

PMC:7200337 / 15504-18766 JSONTXT 11 Projects

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Id Subject Object Predicate Lexical cue
T88 0-208 Sentence denotes While data on COVID-19 patients continues to rapidly emerge, studies of myeloid cell dysfunction in SARS-CoV-1 and MERS-CoV can provide an important roadmap to understanding COVID-19 pathogenesis (Figure 2 ).
T89 209-351 Sentence denotes SARS-CoV-1 infection in mouse models results in an aberrant AM phenotype that limits DC trafficking and T cell activation (Zhao et al., 2009).
T90 352-503 Sentence denotes Additionally, YM1+ FIZZ1+ alternative macrophages can increase airway hypersensitivity, thus exacerbating SARS-associated fibrosis (Page et al., 2012).
T91 504-815 Sentence denotes Further, as described above, murine SARS-CoV-1 studies have demonstrated that delayed IFN-I signaling and inflammatory monocytes-macrophages promote lung cytokine and chemokine levels, vascular leakage, and impaired antigen-specific T cell responses, culminating in lethal disease (Channappanavar et al., 2016).
T92 816-1027 Sentence denotes The role played by prominent IFN-producing pDCs in SARS-CoV-2 control or pathogenesis warrants investigation, as they have been shown to be critical in murine CoV (MHV) control (Cervantes-Barragan et al., 2007).
T93 1028-1379 Sentence denotes Longitudinal studies in SARS-CoV-2 models are awaited, but initial phenotypic studies in humanized hACE2 mice have shown the characteristic alveolar interstitial pneumonia, with infiltration of lymphocytes and monocytes and accumulation of macrophages in the alveolar lumen (Bao et al., 2020a), which recapitulates patient findings (Xu et al., 2020c).
T94 1380-1743 Sentence denotes Lastly, non-human primate (NHP) studies and patient data on SARS-CoV-1 have also shown that virus spike-specific immunoglobulin G (IgG) responses can exacerbate acute lung injury due to repolarization of alveolar macrophages into proinflammatory phenotypes and enhanced recruitment of inflammatory monocyte via CCL2 and IL-8 (Clay et al., 2012, Liu et al., 2019).
T95 1744-1858 Sentence denotes However, the extent to which the antibody response contributes to disease pathophysiology remains to be confirmed.
T96 1859-1952 Sentence denotes Figure 2 SARS-CoV-2 Infection Results in Myeloid Cell Activation and Changes NK Cell Function
T97 1953-2046 Sentence denotes Based on data from preliminary COVID-19 studies and earlier studies in related coronaviruses.
T98 2047-2275 Sentence denotes IL-6, IL-1β, and IFN-I/III from infected pulmonary epithelia can induce inflammatory programs in resident (alternate) macrophages while recruiting inflammatory monocytes, as well as granulocytes and lymphocytes from circulation.
T99 2276-2368 Sentence denotes Sustained IL-6 and TNF-ɑ by incoming monocytes can drive several hyperinflammation cascades.
T100 2369-2491 Sentence denotes Inflammatory monocyte-derived macrophages can amplify dysfunctional responses in various ways (listed in top-left corner).
T101 2492-2629 Sentence denotes The systemic CRS- and sHLH-like inflammatory response can induce neutrophilic NETosis and microthrombosis, aggravating COVID-19 severity.
T102 2630-2726 Sentence denotes Other myeloid cells, such as pDCs, are purported to have an IFN-dependent role in viral control.
T103 2727-2790 Sentence denotes Monocyte-derived CXCL9/10/11 might recruit NK cells from blood.
T104 2791-2951 Sentence denotes Preliminary data suggest that the antiviral function of these NK cells might be regulated through crosstalk with SARS-infected cells and inflammatory monocytes.
T105 2952-2999 Sentence denotes Dashed lines indicate pathways to be confirmed.
T106 3000-3262 Sentence denotes Arg1, arginase 1; iNOS, inducible-nitric oxide synthase; Inflamm., inflammatory; Mono., monocytes; Macs, macrophages; Eosino, eosinophils; Neutro, neutrophils; NETosis, neutrophil extracellular trap cell death; SHLH, secondary hemophagocytic lymphohistiocytosis.