Id |
Subject |
Object |
Predicate |
Lexical cue |
T3 |
0-10 |
Sentence |
denotes |
Background |
T4 |
11-207 |
Sentence |
denotes |
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the causative agent of coronavirus disease 2019 (COVID-19), which has rapidly become epidemic in Italy and other European countries. |
T5 |
208-316 |
Sentence |
denotes |
The disease spectrum ranges from asymptomatic/mildly symptomatic presentations to acute respiratory failure. |
T6 |
317-513 |
Sentence |
denotes |
At the present time the absolute number of severe cases requiring ventilator support is reaching or even surpassing the intensive care unit bed capacity in the most affected regions and countries. |
T7 |
515-525 |
Sentence |
denotes |
Objectives |
T8 |
526-729 |
Sentence |
denotes |
To narratively summarize the available literature on the management of COVID-19 in order to combine current evidence and frontline opinions and to provide balanced answers to pressing clinical questions. |
T9 |
731-738 |
Sentence |
denotes |
Sources |
T10 |
739-802 |
Sentence |
denotes |
Inductive PubMed search for publications relevant to the topic. |
T11 |
804-811 |
Sentence |
denotes |
Content |
T12 |
812-1005 |
Sentence |
denotes |
The available literature and the authors' frontline-based opinion are summarized in brief narrative answers to selected clinical questions, with a conclusive statement provided for each answer. |
T13 |
1007-1019 |
Sentence |
denotes |
Implications |
T14 |
1020-1132 |
Sentence |
denotes |
Many off-label antiviral and anti-inflammatory drugs are currently being administered to patients with COVID-19. |
T15 |
1133-1405 |
Sentence |
denotes |
Physicians must be aware that, as they are not supported by high-level evidence, these treatments may often be ethically justifiable only in those worsening patients unlikely to improve only with supportive care, and who cannot be enrolled onto randomized clinical trials. |
T16 |
1406-1591 |
Sentence |
denotes |
Access to well-designed randomized controlled trials should be expanded as much as possible because it is the most secure way to change for the better our approach to COVID-19 patients. |