PMC:7190487 / 3779-4581 JSONTXT 8 Projects

Annnotations TAB TSV DIC JSON TextAE

Id Subject Object Predicate Lexical cue
T34 0-160 Sentence denotes A study was attempted to narrow the existing molecular-level knowledge gap of SARS-CoV-2 by mapping the interactions between SARS-CoV-2 and human proteins [15].
T35 161-287 Sentence denotes With the help of affinity purification mass spectrometry (AP-MS), 332 protein–protein interactions (PPIs) could be identified.
T36 288-453 Sentence denotes Further, 66 druggable human proteins/factors targeted by 69 medicines which were either FDA-approved or in clinical trials or pre-clinical molecules were recognized.
T37 454-634 Sentence denotes To our interest, it was found that human proteins regulated by the mTORC1 signalling pathway, specifically LARP1 and FKBP7, interact with important viral proteins, N and Orf8 [15].
T38 635-802 Sentence denotes Since metformin inhibits mTOR signalling, it could act as an indirect modulator of the protein–protein complex, thus preventing the viral replication and pathogenesis.