A study was attempted to narrow the existing molecular-level knowledge gap of SARS-CoV-2 by mapping the interactions between SARS-CoV-2 and human proteins [15]. With the help of affinity purification mass spectrometry (AP-MS), 332 protein–protein interactions (PPIs) could be identified. Further, 66 druggable human proteins/factors targeted by 69 medicines which were either FDA-approved or in clinical trials or pre-clinical molecules were recognized. To our interest, it was found that human proteins regulated by the mTORC1 signalling pathway, specifically LARP1 and FKBP7, interact with important viral proteins, N and Orf8 [15]. Since metformin inhibits mTOR signalling, it could act as an indirect modulator of the protein–protein complex, thus preventing the viral replication and pathogenesis.