| Id |
Subject |
Object |
Predicate |
Lexical cue |
| T34 |
0-409 |
Sentence |
denotes |
Immune responses of critically ill patients with sepsis can be classified into three patterns: macrophage-activation syndrome (MAS) (Kyriazopoulou et al., 2017), sepsis-induced immunoparalysis characterized by low expression of the human leukocyte antigen D related (HLA-DR) on CD14 monocytes (Lukaszewicz et al., 2009), and an intermediate functional state of the immune system lacking obvious dysregulation. |
| T35 |
410-508 |
Sentence |
denotes |
We investigated whether this classification might apply to patients with SRF caused by SARS-CoV-2. |
| T36 |
509-815 |
Sentence |
denotes |
Results revealed that approximately one fourth of patients with SRF have MAS and that most patients suffer from immune dysregulation dominated by low expression of HLA-DR on CD14 monocytes, which is triggered by monocyte hyperactivation, excessive release of interleukin-6 (IL-6), and profound lymphopenia. |
| T37 |
816-945 |
Sentence |
denotes |
This pattern is distinct from the immunoparalysis state reported in either bacterial sepsis or SRF caused by 2009 H1N1 influenza. |
