| Id |
Subject |
Object |
Predicate |
Lexical cue |
| T34 |
0-175 |
Sentence |
denotes |
ACE2 is a type I integral membrane glycoprotein (15) expressed predominantly in the bronchus, lung parenchyma, heart, endothelium, kidneys, duodenum, and small intestine (16). |
| T35 |
176-304 |
Sentence |
denotes |
ACE2 is a monocarboxypeptidase, unlike its homolog, ACE, which is a dipeptidase; ACE2 is not antagonized by ACE inhibitors (17). |
| T36 |
305-426 |
Sentence |
denotes |
Although ACE contains 2 active catalytic domains, ACE2 has a single catalytic domain with 42% identical residues (18,19). |
| T37 |
427-557 |
Sentence |
denotes |
The major substrate of ACE2 is Ang II, which upon C-terminus cleavage, produces angiotensin 1-7 (Ang1-7) and L-phenylalanine (20). |
| T38 |
558-678 |
Sentence |
denotes |
Other substrates for ACE2 include Ang I, apelin-13, and dynorphin-13, which are catalyzed at much lower affinities (21). |
| T39 |
679-867 |
Sentence |
denotes |
The non-catalytic C-terminal domain of ACE2 shares a 48% sequence homology with collectrin, a protein involved in neutral amino acid reabsorption from the intestine and the kidney (22,23). |
| T40 |
868-1097 |
Sentence |
denotes |
In the presence of a disintegrin and metalloproteinase 17 (ADAM17), also known as tumor necrosis factor (TNF)-α−converting enzyme (TACE), ACE2 exhibits ectodomain shedding (24), which results in the formation of a soluble enzyme. |
| T41 |
1098-1202 |
Sentence |
denotes |
ACE2 also contains a calmodulin domain on its cytoplasmic tail that influences ectodomain shedding (25). |
