Id |
Subject |
Object |
Predicate |
Lexical cue |
T182 |
0-336 |
Sentence |
denotes |
If SARS-CoV-2 does induce ACE2 ectodomain shedding, which results in the reduction of ACE2 entry sites on the infected cell, it is possible that following transcription S proteins fuse directly at the host cell membrane and directly promote infection of neighboring cells, which results in the formation of multinucleated syncytia (66). |
T183 |
337-475 |
Sentence |
denotes |
Formation of multinucleated cells would allow the virus to spread without being detected or neutralized by virus-specific antibodies (66). |
T184 |
476-653 |
Sentence |
denotes |
Otherwise, following replication and transcription, complete virion assembly in the Golgi would result in transportation of the virus in vesicles and release by exocytosis (66). |
T185 |
654-808 |
Sentence |
denotes |
In the setting of full virion assembly and exocytosis, it is unclear if ACE2 ectodomain shedding would be favorable for further propagation and infection. |