LitCovid-sentences  

PMC:7161517 / 1614-4245 JSONTXT 11 Projects

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Id Subject Object Predicate Lexical cue
T15 0-289 Sentence denotes The novel coronavirus disease-2019 (COVID-19) outbreak, caused by severe acute respiratory syndrome-coronavirus-2 (SARS-CoV-2), originated from the Wuhan, Hubei providence in central China in December 2019 and was declared a pandemic by the World Health Organization on March 11, 2020 (1).
T16 290-413 Sentence denotes Compared with SARS-CoV, which caused the 2002 to 2003 outbreak, SARS-CoV-2 appears to have a stronger rate of transmission.
T17 414-587 Sentence denotes Although the SARS infection exhibits a prolonged clinical course predominantly involving respiratory manifestations, the clinical course of the novel coronavirus is unclear.
T18 588-801 Sentence denotes Further clinical insights from Wuhan suggest that some patients with COVID-19 exhibit severe cardiovascular damage, and those with underlying cardiovascular disease appear to have an increased risk of death (1,2).
T19 802-870 Sentence denotes Both SARS-CoV and CoV2 belong to the beta-coronavirus phylogeny (3).
T20 871-1062 Sentence denotes Although bats may be natural reservoirs for SARS-like coronavirus (3), interspecies transfer of SARS-CoV and SARS-CoV-2 could have occurred through civets (4) and pangolins (5), respectively.
T21 1063-1217 Sentence denotes Both SARS-CoV strains have been identified to use the angiotensin-converting enzyme 2 (ACE2) receptor as the portal of entry into the affected cell (1,4).
T22 1218-1445 Sentence denotes ACE2 is a key modulator of the renin-angiotensin system (RAS), which is a signaling pathway involved in the regulation of vascular function, including the regulation of blood pressure, natriuresis, and blood volume control (6).
T23 1446-1751 Sentence denotes Normally, the RAS involves the formation of angiotensin II (Ang II) through ACE, which contributes to multiple cardiovascular physiological and pathophysiological functions, including hypertension, myocardial hypertrophy, cardiac fibrosis, inflammation, vascular remodeling, and atherosclerosis (7, 8, 9).
T24 1752-2021 Sentence denotes Because of the adverse cardiovascular effects of RAS upregulation, its inhibition through ACE inhibitors, angiotensin II receptor blockers (ARBs), and mineralocorticoid receptor antagonists (MRAs) has been critical for the management of various cardiovascular diseases.
T25 2022-2199 Sentence denotes In the last 2 decades, the identification of ACE2 and its involvement in the counter regulation of the classic RAS has offered a potentially new therapeutic target (10, 11, 12).
T26 2200-2334 Sentence denotes ACE2 exists both as membrane-bound and soluble forms, the former of which mediates SARS-CoV-2 infection via S-protein binding (13,14).
T27 2335-2490 Sentence denotes It is unclear whether SARS-CoV-2 interferes with ACE2 in a manner that contributes to the pathogenesis of SARS or the cardiovascular damage observed (1,2).
T28 2491-2631 Sentence denotes This raises the question of whether RAS inhibition in cardiovascular patients should be reassessed in the setting of this novel coronavirus.