LitCovid-sentences  

PMC:7152526 / 2004-9947 JSONTXT 12 Projects

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Id Subject Object Predicate Lexical cue
T16 0-16 Sentence denotes CASE DESCRIPTION
T17 18-24 Sentence denotes Case 1
T18 25-152 Sentence denotes A previously healthy 71-year-old man visited the Community Health Center on February 22, presenting 12 days of fever and cough.
T19 153-293 Sentence denotes He underwent an examination of SARS-CoV-2 via real-time reverse transcription polymerase chain reaction (rRT-PCR) and diagnosed as COVID-19.
T20 294-397 Sentence denotes He admitted to the local public medical center and 400 mg of hydroxychloroquine once daily was started.
T21 398-538 Sentence denotes A chest radiograph obtained on day 2 showed mild opacities in the right lower lung, lopinavir/ritonavir 400 mg/100 mg twice daily was added.
T22 539-631 Sentence denotes However, on day 3, oxygen demand increased, so he transferred to the tertiary-care hospital.
T23 632-793 Sentence denotes At the time of arrival, the patient had no subjective dyspnea under 4 L/min oxygen flow via nasal cannula, but the respiratory rate was over 30 times per minute.
T24 794-867 Sentence denotes Chest radiographs demonstrated rapidly aggravated bilateral infiltration.
T25 868-974 Sentence denotes Routine blood tests found white blood cell (WBC) count at 3.53 × 103/µL, with lymphopenia of 0.4 × 103/µL.
T26 975-1069 Sentence denotes C-reactive protein (CRP) and lactic dehydrogenase (LDH) elevated up to 59.7 mg/L and 814 IU/L.
T27 1070-1202 Sentence denotes Routine chemistry, electrolyte, and blood coagulation tests revealed no abnormalities except mildly elevated aspartate transaminase.
T28 1203-1266 Sentence denotes The level of interleukin 6 (IL-6) was increased as 101.3 pg/mL.
T29 1267-1376 Sentence denotes Serial bacterial culture and polymerase chain reaction (PCR) for other respiratory viruses were all negative.
T30 1377-1468 Sentence denotes Intubation and mechanical ventilator care were started according to the management of ARDS.
T31 1469-1640 Sentence denotes Despite the continuous use of lopinavir/ritonavir, hydroxychloroquine and empirical antibiotics, he remained febrile with aggravated oxygenation profiles and chest images.
T32 1641-1722 Sentence denotes Laboratory test showed further elevation of CRP (172.6 mg/L), IL-6 (208.2 pg/mL).
T33 1723-1817 Sentence denotes On day 9, the arterial blood gas analysis showed PaO2/FiO2 of 86, consistent with severe ARDS.
T34 1818-1881 Sentence denotes Intravenous methylprednisolone (1 mg/kg/day daily) was started.
T35 1882-1999 Sentence denotes On day 10, convalescent plasma was obtained from a male donor in his 20s who had recovered from COVID-19 for 21 days.
T36 2000-2161 Sentence denotes He was diagnosed as COVID-19 presenting fever, cough and pneumonia, however, showed complete recovery and didn’t have any symptom at the time of plasma donation.
T37 2162-2289 Sentence denotes He has met the blood donor eligibility criteria for plasma donation, including age, weight, reasonable-sized antecubital veins.
T38 2290-2429 Sentence denotes Also, allogeneic donor screening tests, defined by enforcement rules of the Blood Management Act in Korea, were acceptable for transfusion.
T39 2430-2618 Sentence denotes Donor apheresis was performed with Spectra Optia apheresis system (CMNC software; Spectra Optia IDL Tubing set; Terumo BCT, Lakewood, CO, USA), 500 mL of convalescent plasma was collected.
T40 2619-2870 Sentence denotes Anti-SARS-CoV-2 IgG antibody in plasma was measured by enzyme-linked immunosorbent assay (ELISA) (Novel Coronavirus COVID-19 IgG ELISA kit; Epitope Diagnostics, San Diego, CA, USA) and optical density (OD) ratio for IgG was 0.586 (cut-off value 0.22).
T41 2871-2962 Sentence denotes The plasma was divided into two doses and administered to the patient at 12 hours interval.
T42 2963-2999 Sentence denotes Each dose was given over for 1 hour.
T43 3000-3077 Sentence denotes No adverse reaction occurred after the administration of convalescent plasma.
T44 3078-3139 Sentence denotes The fever subsided, and oxygen demand decreased since day 11.
T45 3140-3318 Sentence denotes The patient's condition much improved with decreased CRP and IL-6 to normal range (5.7 mg/L and < 1.5 pg/mL, respectively), and on day 18, PaO2/FiO2 increased up to 300 (Fig. 1).
T46 3319-3395 Sentence denotes A chest X-ray revealed further resolution of both lung infiltrates (Fig. 2).
T47 3396-3621 Sentence denotes SARS-CoV-2 was quantified by detection of the RNA-dependent RNA polymerase region of the ORF1b gene on rRT-PCR, the value of cycle threshold (Ct) changed from 24.98 on day 10 to 33.96 on day 20 after plasma infusion (Fig. 1).
T48 3622-3659 Sentence denotes SARS-CoV-2 was negative after day 26.
T49 3660-3766 Sentence denotes The patient underwent a tracheostomy and currently, is successfully weaned from the mechanical ventilator.
T50 3767-4113 Sentence denotes Fig. 1 Case 1, responses to treatment. (A) Timelines of changes in PaO2/FiO2 and CRP during hospitalization. (B) Timelines of detection of the RNA-dependent RNA polymerase region of the ORF1b gene of severe acute respiratory syndrome coronavirus-2 in sputum by real-time reverse transcription polymerase chain reaction; cycle threshold is shown.
T51 4114-4139 Sentence denotes CRP = C-reactive protein.
T52 4140-4223 Sentence denotes Fig. 2 Chest X-rays of Case 1 taken before and after convalescent plasma infusion.
T53 4224-4292 Sentence denotes Taken on day 7, just before the convalescent plasma infusion (left).
T54 4293-4369 Sentence denotes Taken on day 13 shows marked improvement of bilateral infiltrations (right).
T55 4370-4426 Sentence denotes The images are published under agreement of the patient.
T56 4428-4434 Sentence denotes Case 2
T57 4435-4582 Sentence denotes A 67-year-old woman with a medical history of hypertension developed fever and myalgia and diagnosed as COVID-19 via SARS-CoV-2 rRT-PCR on March 6.
T58 4583-4774 Sentence denotes The next day, she was admitted to a local public medical center and received hydroxychloroquine 400 mg once daily and lopinavir/ritonavir 400 mg/100 mg twice daily with empirical antibiotics.
T59 4775-4933 Sentence denotes However, on day 3, she was transferred to the tertiary-care hospital due to increased oxygen demand and worsening infiltrative shadows in the left lower lung.
T60 4934-5070 Sentence denotes At that time, her oxygen saturation checked 93% on 4 L/min oxygen flow via nasal cannula with a respiratory rate of 24 times per minute.
T61 5071-5328 Sentence denotes Routine blood tests showed mild leukocytosis (12.67 × 103/µL) with lymphopenia (0.7 × 103/µL), elevated CRP, IL-6 and LDH. (131.1 mg/L, 474.7 pg/mL, 344 IU/L, respectively) Routine chemistry, electrolyte, and blood coagulation tests showed no abnormalities.
T62 5329-5408 Sentence denotes Bacterial cultures and the PCR for other respiratory viruses were all negative.
T63 5409-5571 Sentence denotes She received high flow oxygen therapy but bilateral infiltration and oxygenation were deteriorated, so intubation and mechanical ventilator care started on day 4.
T64 5572-5640 Sentence denotes Intravenous methylprednisolone (0.5 mg/kg/day daily) was also added.
T65 5641-5774 Sentence denotes She had sustained high fever with rapidly increasing CRP (314 mg/L), WBC (21.79 × 103/µL), and persistent lymphopenia (0.5 × 103/µL).
T66 5775-5825 Sentence denotes PaO2/FiO2 fell to 76, consistent with severe ARDS.
T67 5826-5982 Sentence denotes After applying for the prone position according to the management of ARDS with the use of steroids, chest images and the oxygen demand began to be improved.
T68 5983-6099 Sentence denotes On day 6, convalescent plasma was obtained from a male donor in his 20s who had recovered from COVID-19 for 18 days.
T69 6100-6275 Sentence denotes He was diagnosed as COVID-19 presenting fever, cough and pneumonia however, showed complete recovery and serial PCRs for SARS-CoV-2 were all negative after hospital discharge.
T70 6276-6362 Sentence denotes Donor screening and plasma collection were performed as mentioned above in the Case 1.
T71 6363-6463 Sentence denotes OD ratio for IgG was 0.532 and the plasma was administered to the patient in the same way as Case 1.
T72 6464-6524 Sentence denotes There was no adverse reaction during the plasma transfusion.
T73 6525-6616 Sentence denotes Leukocytosis and lymphopenia were immediately recovered after convalescent plasma infusion.
T74 6617-6726 Sentence denotes On day 9, the density of bilateral infiltration on chest X-ray much improved with increased PaO2/FiO2 to 230.
T75 6727-6794 Sentence denotes The level of CRP and IL-6 also recovered to the normal range (Figs.
T76 6795-6804 Sentence denotes 3 and 4).
T77 6805-6936 Sentence denotes SARS-CoV-2 was quantified by rRT-PCR; the value of Ct changed from 20.51 on day 5 to 36.33 on day 9 after plasma infusion (Fig. 3).
T78 6937-7018 Sentence denotes The patient is successfully extubated and discharged from the hospital on day 24.
T79 7019-7056 Sentence denotes SARS-CoV-2 was negative after day 20.
T80 7057-7403 Sentence denotes Fig. 3 Case 2, responses to treatment. (A) Timelines of changes in PaO2/FiO2 and CRP during hospitalization. (B) Timelines of detection of the RNA-dependent RNA polymerase region of the ORF1b gene of severe acute respiratory syndrome coronavirus-2 in sputum by real-time reverse transcription polymerase chain reaction; cycle threshold is shown.
T81 7404-7429 Sentence denotes CRP = C-reactive protein.
T82 7430-7513 Sentence denotes Fig. 4 Chest X-rays of Case 2 taken before and after convalescent plasma infusion.
T83 7514-7577 Sentence denotes Taken on day 2, before the convalescent plasma infusion (left).
T84 7578-7653 Sentence denotes Taken on day 6 shows marked improvement of bilateral infiltrations (right).
T85 7654-7710 Sentence denotes The images are published under agreement of the patient.
T86 7712-7728 Sentence denotes Ethics statement
T87 7729-7823 Sentence denotes This study was approved by the Institutional Review Board (IRB) of Severance Hospital (IRB No.
T88 7824-7885 Sentence denotes 4-2020-0076) and with participants' written informed consent.
T89 7886-7943 Sentence denotes The images are published under agreement of the patients.