LitCovid-sentences  

PMC:7148425 / 7060-8565 JSONTXT 11 Projects

Annnotations TAB TSV DIC JSON TextAE

Id Subject Object Predicate Lexical cue
T40 0-34 Sentence denotes Biomarkers and vaccine requirement
T41 35-78 Sentence denotes There are few precedents to assist us here.
T42 79-183 Sentence denotes Efforts to develop a prophylactic vaccine or SARS-CoV-1 were shelved when the infection faded by itself.
T43 184-307 Sentence denotes There are surprisingly few data available concerning the status of immune responsiveness to truly novel antigens in humans.
T44 308-528 Sentence denotes A study on Yellow Fever vaccination of the elderly pointed to dysfunctional antigen-presenting cells and a dearth of antigen-specific CD4+ Th helper cells as culprits in the low antibody responses of older vaccinees [7].
T45 529-621 Sentence denotes Otherwise, we have to rely mostly on the large literature on seasonal influenza vaccination.
T46 622-797 Sentence denotes However, the problem here is that everyone has already been exposed to some strains of influenza and even newly-emerging strains such as the avian H7N1 are not entirely novel.
T47 798-972 Sentence denotes Nonetheless, knowledge garnered on immunity and responses to vaccination against this virus may tell us something about the capacity of older adults to respond to SARS-CoV-2.
T48 973-1081 Sentence denotes Primate models featuring the responses of older monkeys to SARS-CoV-1 infection may also be informative [8].
T49 1082-1331 Sentence denotes A systems biology approach will be needed to identify the protective antigen/epitopes of SARS-CoV-2 for both antibody/B cell responses and T cell responses and to classify them as protective or non-protective responses to serve as useful biomarkers.
T50 1332-1505 Sentence denotes Importantly, vaccine design for the older adult should aim to stimulate a broad T and B cell response potentially overcoming reduced immune function in the older population.