| Id |
Subject |
Object |
Predicate |
Lexical cue |
| T28 |
0-249 |
Sentence |
denotes |
One important characteristic of human coronaviruses is that besides their protein membrane receptor, they also depend upon sialic-acid-containing glycoproteins and gangliosides that act as primary attachment factors along the respiratory tract [10]. |
| T29 |
250-411 |
Sentence |
denotes |
The present study used a combination of structural and molecular modelling approaches [11] to investigate the potential interaction between CLQ and sialic acids. |
| T30 |
412-750 |
Sentence |
denotes |
A ganglioside-binding site in the N-terminal domain (NTD) of the spike (S) glycoprotein of SARS-CoV-2 was identified, and CLQ was shown to be a potential blocker of the S–ganglioside interaction which occurs in the first step of the viral replication cycle (i.e. attachment to the surface of respiratory cells, mediated by the S protein). |
| T31 |
751-875 |
Sentence |
denotes |
In addition, the antiviral potential of CLQ and its derivative hydroxychloroquine (CLQ-OH) against SARS-CoV-2 were compared. |
| T32 |
876-1020 |
Sentence |
denotes |
Overall, this study found that CLQ and CLQ-OH may be used to fight pathogenic human coronaviruses [3], [4], [5], [6], including SARS-CoV-2 [12]. |
