PMC:7111504 / 3451-5931 JSONTXT 12 Projects

Annnotations TAB TSV DIC JSON TextAE

Id Subject Object Predicate Lexical cue
T27 0-111 Sentence denotes Identification of 28 exact matches to SARS CoV immunogenic peptides by screening all epitopes deposited in IEDB
T28 112-240 Sentence denotes We collected all peptides in IEDB ( 3, as of 13-02-2020) reported positive in T cell assays and have human as the host organism.
T29 241-386 Sentence denotes We then conducted a local sequence alignment of 10 2019-nCoV open reading frames (ORFs) against 35,225 IEDB peptides, and found 28 exact matches.
T30 387-523 Sentence denotes Surprisingly, all identical hits (against peptides having sequence length greater than 3) were from SARS-CoV ( Table 1, Data Table 1 4).
T31 524-724 Sentence denotes These peptides have been shown to bind various HLA alleles, although with higher tendency towards HLA-A:02:01, from both class I and class II, and can be target for CD8+ and CD4+ T cells respectively.
T32 725-733 Sentence denotes Table 1.
T33 735-813 Sentence denotes 28 2019-nCoV peptides having exact matches with immunogenic SARS-CoV peptides.
T34 814-872 Sentence denotes IEDB.peptide 2019-nCoV.pattern Antigen.Name Allele.Name
T35 873-932 Sentence denotes TLACFVLAAV TLACFVLAAV Membrane glycoprotein HLA-A *02:01
T36 933-982 Sentence denotes AFFGMSRIGMEVTPSGTW AFFGMSRIGMEVTPSGTW N protein
T37 983-1032 Sentence denotes ALNTPKDHI ALNTPKDHI Nucleoprotein HLA-A *02:01
T38 1033-1101 Sentence denotes AQFAPSASAFFGMSR AQFAPSASAFFGMSR nucleocapsid protein HLA class II
T39 1102-1151 Sentence denotes AQFAPSASAFFGMSRIGM AQFAPSASAFFGMSRIGM N protein
T40 1152-1201 Sentence denotes GMSRIGMEV GMSRIGMEV Nucleoprotein HLA-A *02:01
T41 1202-1251 Sentence denotes ILLNKHIDA ILLNKHIDA Nucleoprotein HLA-A *02:01
T42 1252-1299 Sentence denotes IRQGTDYKHWPQIAQFA IRQGTDYKHWPQIAQFA N protein
T43 1300-1347 Sentence denotes KHWPQIAQFAPSASAFF KHWPQIAQFAPSASAFF N protein
T44 1348-1397 Sentence denotes LALLLLDRL LALLLLDRL Nucleoprotein HLA-A *02:01
T45 1398-1447 Sentence denotes LLLDRLNQL LLLDRLNQL Nucleoprotein HLA-A *02:01
T46 1448-1497 Sentence denotes LLNKHIDAYKTFPPTEPK LLNKHIDAYKTFPPTEPK N protein
T47 1498-1547 Sentence denotes LQLPQGTTL LQLPQGTTL Nucleoprotein HLA-A *02:01
T48 1548-1615 Sentence denotes RRPQGLPNNTASWFT RRPQGLPNNTASWFT nucleocapsid protein HLA class I
T49 1616-1661 Sentence denotes YKTFPPTEPKKDKKKK YKTFPPTEPKKDKKKK N protein
T50 1662-1709 Sentence denotes ILLNKHID ILLNKHID Nucleoprotein HLA-A *02:01
T51 1710-1768 Sentence denotes MEVTPSGTWL MEVTPSGTWL nucleocapsid protein HLA-B *40:01
T52 1769-1814 Sentence denotes ALNTLVKQL ALNTLVKQL S protein HLA-A *02:01
T53 1815-1873 Sentence denotes FIAGLIAIV FIAGLIAIV Spike glycoprotein precursor HLA-A2
T54 1874-1932 Sentence denotes LITGRLQSL LITGRLQSL Spike glycoprotein precursor HLA-A2
T55 1933-1978 Sentence denotes NLNESLIDL NLNESLIDL S protein HLA-A *02:01
T56 1979-2043 Sentence denotes QALNTLVKQLSSNFGAI QALNTLVKQLSSNFGAI S protein HLA-DRB1 *04:01
T57 2044-2108 Sentence denotes RLNEVAKNL RLNEVAKNL Spike glycoprotein precursor HLA-A *02:01
T58 2109-2154 Sentence denotes VLNDILSRL VLNDILSRL S protein HLA-A *02:01
T59 2155-2219 Sentence denotes VVFLHVTYV VVFLHVTYV Spike glycoprotein precursor HLA-A *02:01
T60 2220-2293 Sentence denotes GAALQIPFAMQMAYRF GAALQIPFAMQMAYRF S protein HLA-DRA *01:01/DRB1 *07:01
T61 2294-2356 Sentence denotes MAYRFNGIGVTQNVLY MAYRFNGIGVTQNVLY S protein HLA-DRB1 *04:01
T62 2357-2423 Sentence denotes QLIRAAEIRASANLAATK QLIRAAEIRASANLAATK S protein HLA-DRB1 *04:01
T63 2424-2434 Sentence denotes *SARS-CoV:
T64 2435-2480 Sentence denotes Severe acute respiratory syndrome coronavirus