Id |
Subject |
Object |
Predicate |
Lexical cue |
T27 |
0-111 |
Sentence |
denotes |
Identification of 28 exact matches to SARS CoV immunogenic peptides by screening all epitopes deposited in IEDB |
T28 |
112-240 |
Sentence |
denotes |
We collected all peptides in IEDB ( 3, as of 13-02-2020) reported positive in T cell assays and have human as the host organism. |
T29 |
241-386 |
Sentence |
denotes |
We then conducted a local sequence alignment of 10 2019-nCoV open reading frames (ORFs) against 35,225 IEDB peptides, and found 28 exact matches. |
T30 |
387-523 |
Sentence |
denotes |
Surprisingly, all identical hits (against peptides having sequence length greater than 3) were from SARS-CoV ( Table 1, Data Table 1 4). |
T31 |
524-724 |
Sentence |
denotes |
These peptides have been shown to bind various HLA alleles, although with higher tendency towards HLA-A:02:01, from both class I and class II, and can be target for CD8+ and CD4+ T cells respectively. |
T32 |
725-733 |
Sentence |
denotes |
Table 1. |
T33 |
735-813 |
Sentence |
denotes |
28 2019-nCoV peptides having exact matches with immunogenic SARS-CoV peptides. |
T34 |
814-872 |
Sentence |
denotes |
IEDB.peptide 2019-nCoV.pattern Antigen.Name Allele.Name |
T35 |
873-932 |
Sentence |
denotes |
TLACFVLAAV TLACFVLAAV Membrane glycoprotein HLA-A *02:01 |
T36 |
933-982 |
Sentence |
denotes |
AFFGMSRIGMEVTPSGTW AFFGMSRIGMEVTPSGTW N protein |
T37 |
983-1032 |
Sentence |
denotes |
ALNTPKDHI ALNTPKDHI Nucleoprotein HLA-A *02:01 |
T38 |
1033-1101 |
Sentence |
denotes |
AQFAPSASAFFGMSR AQFAPSASAFFGMSR nucleocapsid protein HLA class II |
T39 |
1102-1151 |
Sentence |
denotes |
AQFAPSASAFFGMSRIGM AQFAPSASAFFGMSRIGM N protein |
T40 |
1152-1201 |
Sentence |
denotes |
GMSRIGMEV GMSRIGMEV Nucleoprotein HLA-A *02:01 |
T41 |
1202-1251 |
Sentence |
denotes |
ILLNKHIDA ILLNKHIDA Nucleoprotein HLA-A *02:01 |
T42 |
1252-1299 |
Sentence |
denotes |
IRQGTDYKHWPQIAQFA IRQGTDYKHWPQIAQFA N protein |
T43 |
1300-1347 |
Sentence |
denotes |
KHWPQIAQFAPSASAFF KHWPQIAQFAPSASAFF N protein |
T44 |
1348-1397 |
Sentence |
denotes |
LALLLLDRL LALLLLDRL Nucleoprotein HLA-A *02:01 |
T45 |
1398-1447 |
Sentence |
denotes |
LLLDRLNQL LLLDRLNQL Nucleoprotein HLA-A *02:01 |
T46 |
1448-1497 |
Sentence |
denotes |
LLNKHIDAYKTFPPTEPK LLNKHIDAYKTFPPTEPK N protein |
T47 |
1498-1547 |
Sentence |
denotes |
LQLPQGTTL LQLPQGTTL Nucleoprotein HLA-A *02:01 |
T48 |
1548-1615 |
Sentence |
denotes |
RRPQGLPNNTASWFT RRPQGLPNNTASWFT nucleocapsid protein HLA class I |
T49 |
1616-1661 |
Sentence |
denotes |
YKTFPPTEPKKDKKKK YKTFPPTEPKKDKKKK N protein |
T50 |
1662-1709 |
Sentence |
denotes |
ILLNKHID ILLNKHID Nucleoprotein HLA-A *02:01 |
T51 |
1710-1768 |
Sentence |
denotes |
MEVTPSGTWL MEVTPSGTWL nucleocapsid protein HLA-B *40:01 |
T52 |
1769-1814 |
Sentence |
denotes |
ALNTLVKQL ALNTLVKQL S protein HLA-A *02:01 |
T53 |
1815-1873 |
Sentence |
denotes |
FIAGLIAIV FIAGLIAIV Spike glycoprotein precursor HLA-A2 |
T54 |
1874-1932 |
Sentence |
denotes |
LITGRLQSL LITGRLQSL Spike glycoprotein precursor HLA-A2 |
T55 |
1933-1978 |
Sentence |
denotes |
NLNESLIDL NLNESLIDL S protein HLA-A *02:01 |
T56 |
1979-2043 |
Sentence |
denotes |
QALNTLVKQLSSNFGAI QALNTLVKQLSSNFGAI S protein HLA-DRB1 *04:01 |
T57 |
2044-2108 |
Sentence |
denotes |
RLNEVAKNL RLNEVAKNL Spike glycoprotein precursor HLA-A *02:01 |
T58 |
2109-2154 |
Sentence |
denotes |
VLNDILSRL VLNDILSRL S protein HLA-A *02:01 |
T59 |
2155-2219 |
Sentence |
denotes |
VVFLHVTYV VVFLHVTYV Spike glycoprotein precursor HLA-A *02:01 |
T60 |
2220-2293 |
Sentence |
denotes |
GAALQIPFAMQMAYRF GAALQIPFAMQMAYRF S protein HLA-DRA *01:01/DRB1 *07:01 |
T61 |
2294-2356 |
Sentence |
denotes |
MAYRFNGIGVTQNVLY MAYRFNGIGVTQNVLY S protein HLA-DRB1 *04:01 |
T62 |
2357-2423 |
Sentence |
denotes |
QLIRAAEIRASANLAATK QLIRAAEIRASANLAATK S protein HLA-DRB1 *04:01 |
T63 |
2424-2434 |
Sentence |
denotes |
*SARS-CoV: |
T64 |
2435-2480 |
Sentence |
denotes |
Severe acute respiratory syndrome coronavirus |