LitCovid-sentences  

PMC:7105881 / 22393-26043 JSONTXT 11 Projects

Annnotations TAB TSV DIC JSON TextAE

Id Subject Object Predicate Lexical cue
T137 0-75 Sentence denotes Potential Targets for Development of SARS-CoV and MERS-CoV Subunit Vaccines
T138 76-174 Sentence denotes The S protein of SARS-CoV and MERS-CoV plays a vital role in receptor binding and membrane fusion.
T139 175-472 Sentence denotes Thus, the S protein, but not other structural proteins, is the major antigen to induce protective neutralizing antibodies to block viruses from binding their respective receptor and thus inhibit viral infection (Bisht et al., 2004; Buchholz et al., 2004; Bukreyev et al., 2004; Yang et al., 2004).
T140 473-593 Sentence denotes As a result, the S protein is also a major target for the development of subunit vaccines against SARS-CoV and MERS-CoV.
T141 594-866 Sentence denotes Both full-length S protein and its antigenic fragments, including S1 subunit, NTD, RBD, and S2 subunit, can serve as important targets for the development of subunit vaccines (Guo et al., 2005; Mou et al., 2013; Wang et al., 2015; Jiaming et al., 2017; Zhou et al., 2018).
T142 867-1289 Sentence denotes Although subunit vaccines based on the full-length S protein may elicit potent immune responses and/or protection, studies have found that antibodies induced by some of these vaccines mediate enhancement of viral infection in vitro, as in the case of SARS-CoV (Kam et al., 2007; Jaume et al., 2012), raising safety concerns for the development of full-length S protein-based subunit vaccines against SARS-CoV and MERS-CoV.
T143 1290-1418 Sentence denotes In contrast, RBD-based subunit vaccines comprise the major critical neutralizing domain (Du and Jiang, 2015; Zhou et al., 2019).
T144 1419-1545 Sentence denotes Therefore, these vaccines may generate potent neutralizing antibodies with strong protective immunity against viral infection.
T145 1546-1756 Sentence denotes S1 subunit, for example, is much shorter than the full-length S protein, but it is no less able to induce strong immune responses and/or protection against viral infection (Li et al., 2013; Adney et al., 2019).
T146 1757-1846 Sentence denotes Thus, this fragment can be used as an alternative target for subunit vaccine development.
T147 1847-2186 Sentence denotes Despite their ability to induce immune responses and/or neutralizing antibodies, NTD and S2 as the targets of subunit vaccines are less immunogenic, eliciting significantly lower antibody titers, cellular immune responses, and/or protection than the other regions, such as full-length, S1, and RBD (Guo et al., 2005; Jiaming et al., 2017).
T148 2187-2402 Sentence denotes Therefore, in terms of safety and efficacy, the RBD and/or S1 of S protein could be applied as critical targets for the development of subunit vaccine candidates against SARS-CoV, MERS-CoV, SARSr-CoV, and MERSr-CoV.
T149 2403-2669 Sentence denotes Because of its conserved amino acid sequences and high homology among different virus strains (Elshabrawy et al., 2012; Zhou et al., 2018), the S2 subunit has potential to be used as a target for the development of universal vaccines against divergent virus strains.
T150 2670-2813 Sentence denotes In addition to the S protein, the N protein of SARS-CoV and MERS-CoV may serve as an additional target for the development of subunit vaccines.
T151 2814-3068 Sentence denotes Unlike S protein, the N protein has no ability to elicit neutralizing antibodies to block virus-receptor interaction and neutralize viral infection, but it may induce specific antibody and cellular immune responses (Liu et al., 2006; Zheng et al., 2009).
T152 3069-3308 Sentence denotes Several immunodominant B-cell and T-cell epitopes have been identified in the N protein of SARS-CoV and MERS-CoV, some of which are conserved in mice, non-human primates, and humans (Liu et al., 2006; Chan et al., 2011; Veit et al., 2018).
T153 3309-3419 Sentence denotes Other proteins, such as M protein, can be used as potential targets of SARS-CoV and MERS-CoV subunit vaccines.
T154 3420-3650 Sentence denotes Notably, SARS-CoV M protein-derived peptides have immunogenicity to induce high-titer antibody responses in the immunized animals (He et al., 2005b), suggesting the potential for utilizing this protein to develop subunit vaccines.