| Id |
Subject |
Object |
Predicate |
Lexical cue |
| T181 |
0-4 |
Sentence |
denotes |
3.9. |
| T182 |
5-25 |
Sentence |
denotes |
Proteomic Comparison |
| T183 |
26-188 |
Sentence |
denotes |
To further explore whether all encoded proteins of SARS-CoV-2 are homologous to that of SARS-CoV, we performed a protein sequence alignment analysis using Blastp. |
| T184 |
189-390 |
Sentence |
denotes |
The results showed that most of SARS-CoV-2 proteins are highly homologous (95%–100%) to the proteins of SARS-CoV virus, indicating the evolutionary similarity between SARS-CoV and SARS-CoV-2 (Table 2). |
| T185 |
391-484 |
Sentence |
denotes |
However, two proteins (orf8 and orf10) in SARS-CoV-2 have no homologous proteins in SARS-CoV. |
| T186 |
485-619 |
Sentence |
denotes |
The amino acid sequence of orf8 in SARS-CoV-2 is different from sequences of conserved orf8 or orf8b derived from human SARS-CoV [11]. |
| T187 |
620-697 |
Sentence |
denotes |
Orf8 protein of SARS-CoV-2 does not contain known functional domain or motif. |
| T188 |
698-925 |
Sentence |
denotes |
An aggregation motif VLVVL (amino acid 75–79) has been found in SARS-CoV orf8b which was shown to trigger intracellular stress pathways and activate NOD-like receptor family pyrin domain-containing-3 (NLRP3) inflammasomes [90]. |
| T189 |
926-1067 |
Sentence |
denotes |
Therefore, it will be clinically meaningful to analyze the biological function of these two specific proteins (orf8 and orf10) in SARS-CoV-2. |
| T190 |
1068-1168 |
Sentence |
denotes |
As the most abundant protein in CoVs, nucleocapsid (N) protein is highly conserved across CoVs [91]. |
| T191 |
1169-1391 |
Sentence |
denotes |
The N protein in SARS-CoV-2 shares ~90% amino acid identity with that in SARS-CoV [28], which indicates that antibodies against the N protein of SARS-CoV would likely recognize and bind the N protein of SARS-CoV-2 as well. |
| T192 |
1392-1628 |
Sentence |
denotes |
N antibodies do not provide immunity to SARS-CoV-2 infection, but the antibodies have a cross reactivity with SARS-CoV N protein viruses, which would allow a serum-based assay to identify the asymptomatic SARS-CoV-2 infected-cases [28]. |
| T193 |
1629-1830 |
Sentence |
denotes |
Although previous studies have found serum reactivity to group SARS-CoV N proteins in Chinese populations [92], exposure to SARS-CoV-2 should increase the dilution factor if the infection had occurred. |
| T194 |
1831-1928 |
Sentence |
denotes |
This information has important implications for preventing the spread of asymptomatic infections. |
| T195 |
1929-2117 |
Sentence |
denotes |
In addition, spike stalk S2 in SARS-CoV-2 is highly conserved and shares 99% identity with those of the two bat SARS-like CoVs (bat-SL-CoVZXC21 and bat-SL-CoVZC45) and human SARS-CoV [11]. |
| T196 |
2118-2222 |
Sentence |
denotes |
Thus, the broad spectrum antiviral peptides against S2 has the potential to be effective treatment [93]. |
