LitCovid-sentences  

PMC:7075884 / 62-1853 JSONTXT 11 Projects

Annnotations TAB TSV DIC JSON TextAE

Id Subject Object Predicate Lexical cue
T3 0-92 Sentence denotes Ginkgolic acids (GA) are alkylphenol constituents of the leaves and fruits of Ginkgo biloba.
T4 93-345 Sentence denotes GA has shown pleiotropic effects in vitro, including: antitumor effects through inhibition of lipogenesis; decreased expression of invasion associated proteins through AMPK activation; and potential rescue of amyloid-β (Aβ) induced synaptic impairment.
T5 346-435 Sentence denotes GA was also reported to have activity against Escherichia coli and Staphylococcus aureus.
T6 436-687 Sentence denotes Several mechanisms for this activity have been suggested including: SUMOylation inhibition; blocking formation of the E1-SUMO intermediate; inhibition of fatty acid synthase; non-specific SIRT inhibition; and activation of protein phosphatase type-2C.
T7 688-813 Sentence denotes Here we report that GA inhibits Herpes simplex virus type 1 (HSV-1) by inhibition of both fusion and viral protein synthesis.
T8 814-968 Sentence denotes Additionally, we report that GA inhibits human cytomegalovirus (HCMV) genome replication and Zika virus (ZIKV) infection of normal human astrocytes (NHA).
T9 969-1149 Sentence denotes We show a broad spectrum of fusion inhibition by GA of all three classes of fusion proteins including HIV, Ebola virus (EBOV), influenza A virus (IAV) and Epstein Barr virus (EBV).
T10 1150-1212 Sentence denotes In addition, we show inhibition of a non-enveloped adenovirus.
T11 1213-1304 Sentence denotes Our experiments suggest that GA inhibits virion entry by blocking the initial fusion event.
T12 1305-1474 Sentence denotes Data showing inhibition of HSV-1 and CMV replication, when GA is administered post-infection, suggest a possible secondary mechanism targeting protein and DNA synthesis.
T13 1475-1791 Sentence denotes Thus, in light of the strong effect of GA on viral infection, even after the infection begins, it may potentially be used to treat acute infections (e.g. Coronavirus, EBOV, ZIKV, IAV and measles), and also topically for the successful treatment of active lesions (e.g. HSV-1, HSV-2 and varicella-zoster virus (VZV)).