| Id |
Subject |
Object |
Predicate |
Lexical cue |
| T148 |
0-20 |
Sentence |
denotes |
Papain-like protease |
| T149 |
21-455 |
Sentence |
denotes |
The PLpro cleaves the N-terminal region of the PP to generate three NSPs (NSP 1, 2, and 3).[374] PLpro has a catalytic core domain that contains 316 amino acid, which is responsible for cleaving replicase substrates, and a consensus sequence LXGG was required for cleavage.[78] Higher doses of zinc and zinc conjugates were found to inhibit both types of SARS protease (CLpro and PLpro).[84] Benzodioxole can inhibit the PLpro enzyme. |
| T150 |
456-512 |
Sentence |
denotes |
The crystal structure of interaction is shown in PDB ID: |
| T151 |
513-937 |
Sentence |
denotes |
4OVZ, 4OWZ.[31] Through in silico approach, another new lead was identified (6577871) which was further optimized, and compound 15h (S configuration, enzyme IC50 =0.56 μM, antiviral EC50 =9.1 μM) and 15g (R configuration, enzyme IC50 =0.32 μM; antiviral EC50 =9.1 μM) were found to be the most important inhibitors.[32] The crystallized structural details of these interactions can be visualized in the PDB database (PDB ID: |
| T152 |
938-957 |
Sentence |
denotes |
2FE8 and 3E9S).[32] |
| T153 |
958-1078 |
Sentence |
denotes |
Many of the protease inhibitors are being used in the treatment of COVID-19, e.g., lopinavir–ritonavir combinations.[85] |
