LitCovid-sentences  

PMC:7067204 / 16949-18513 JSONTXT 13 Projects

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Id Subject Object Predicate Lexical cue
T181 0-5 Sentence denotes Orf3b
T182 6-145 Sentence denotes A novel short putative protein with 4 helices and no homology to existing SARS-CoV or SARS-r-CoV protein was found within Orf3b (Figure 4).
T183 146-357 Sentence denotes It is notable that SARS-CoV deletion mutants lacking orf3b replicate to levels similar to those of wild-type virus in several cell types [19], suggesting that orf3b is dispensable for viral replication in vitro.
T184 358-613 Sentence denotes But orf3b may have a role in viral pathogenicity as Vero E6 but not 293T cells transfected with a construct expressing Orf3b underwent necrosis as early as 6 h after transfection and underwent simultaneous necrosis and apoptosis at later time points [20].
T185 614-699 Sentence denotes Orf3b was also shown to inhibit expression of IFN-β at synthesis and signalling [21].
T186 700-881 Sentence denotes Subsequently, orf3b homologues identified from three bat SARS-related-CoV strains were C-terminally truncated and lacked the C-terminal nucleus localization signal of SARS-CoV [22].
T187 882-1022 Sentence denotes IFN antagonist activity analysis demonstrated that one SARS-related-CoV orf3b still possessed IFN antagonist and IRF3-modulating activities.
T188 1023-1282 Sentence denotes These results indicated that different orf3b proteins display different IFN antagonist activities and this function is independent of the protein's nuclear localization, suggesting a potential link between bat SARS-related-CoV orf3b function and pathogenesis.
T189 1283-1373 Sentence denotes The importance of this new protein in 2019-nCoV will require further validation and study.
T190 1374-1383 Sentence denotes Figure 4.
T191 1384-1402 Sentence denotes Analysis of orf3b.
T192 1403-1405 Sentence denotes A.
T193 1406-1514 Sentence denotes Multiple alignment of orf3b protein sequence between 2019-nCoV (HKU-SZ-005b), SARS-CoV and SARS-related CoV.
T194 1515-1517 Sentence denotes B.
T195 1518-1564 Sentence denotes A novel putative short protein found in orf3b.