LitCovid-sentences  

PMC:7067204 / 13205-16947 JSONTXT 13 Projects

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Id Subject Object Predicate Lexical cue
T155 0-51 Sentence denotes Spike glycoprotein comprised of S1 and S2 subunits.
T156 52-312 Sentence denotes The S1 subunit contains a signal peptide, followed by an N-terminal domain (NTD) and receptor-binding domain (RBD), while the S2 subunit contains conserved fusion peptide (FP), heptad repeat (HR) 1 and 2, transmembrane domain (TM), and cytoplasmic domain (CP).
T157 313-494 Sentence denotes We found that the S2 subunit of 2019-nCoV is highly conserved and shares 99% identity with those of the two bat SARS-like CoVs (SL-CoV ZXC21 and ZC45) and human SARS-CoV (Figure 2).
T158 495-662 Sentence denotes Thus the broad spectrum antiviral peptides against S2 would be an important preventive and treatment modality for testing in animal models before clinical trials [18].
T159 663-890 Sentence denotes Though the S1 subunit of 2019-nCoV shares around 70% identity to that of the two bat SARS-like CoVs and human SARS-CoV (Figure 3(A)), the core domain of RBD (excluding the external subdomain) are highly conserved (Figure 3(B)).
T160 891-1043 Sentence denotes Most of the amino acid differences of RBD are located in the external subdomain, which is responsible for the direct interaction with the host receptor.
T161 1044-1192 Sentence denotes Further investigation of this soluble variable external subdomain region will reveal its receptor usage, interspecies transmission and pathogenesis.
T162 1193-1373 Sentence denotes Unlike 2019-nCoV and human SARS-CoV, most known bat SARSr-CoVs have two stretches of deletions in the spike receptor binding domain (RBD) when compared with that of human SARS-CoV.
T163 1374-1489 Sentence denotes But some Yunnan strains such as the WIV1 had no such deletions and can use human ACE2 as a cellular entry receptor.
T164 1490-1716 Sentence denotes It is interesting to note that the two bat SARS-related coronavirus ZXC21 and ZC45, being closest to 2019-nCoV, can infect suckling rats and cause inflammation in the brain tissue, and pathological changes in lung & intestine.
T165 1717-1817 Sentence denotes However, these two viruses could not be isolated in Vero E6 cells and were not investigated further.
T166 1818-1975 Sentence denotes The two retained deletion sites in the Spike genes of ZXC21 and ZC45 may lessen their likelihood of jumping species barriers imposed by receptor specificity.
T167 1976-1985 Sentence denotes Figure 2.
T168 1986-2044 Sentence denotes Comparison of protein sequences of Spike stalk S2 subunit.
T169 2045-2413 Sentence denotes Multiple alignment of Spike S2 amino acid sequences of 2019-nCoV HKU-SZ-005b (accession number MN975262), bat SARS-like coronavirus isolates bat-SL-CoVZXC21 and bat-SL-CoVZXC45 (accession number MG772934.1 and MG772933.1, respectively) and human SARS coronavirus (accession number NC004718) was performed and displayed using CLUSTAL 2.1 and BOXSHADE 3.21 respectively.
T170 2414-2532 Sentence denotes The black boxes represent the identity while the grey boxes represent the similarity of the four amino acid sequences.
T171 2533-2542 Sentence denotes Figure 3.
T172 2543-2580 Sentence denotes Comparison of protein sequences of A.
T173 2581-2611 Sentence denotes Spike globular head S1, and B.
T174 2612-2653 Sentence denotes S1 receptor-binding domain (RBD) subunit.
T175 2654-3203 Sentence denotes Multiple alignment of Spike S1 amino acid sequences of 2019-nCoV HKU-SZ-005b (accession number MN975262), bat SARS-like coronavirus isolates bat-SL-CoVZXC21, bat-SL-CoVZXC45, bat-SL-CoV-YNLF_31C, bat-SL-CoV-YNLF_34C and bat SL-CoV HKU3-1 (accession number MG772934.1 and MG772933.1, KP886808, KP886809 and DQ022305, respectively), human SARS coronavirus GZ02 and Tor2 (accession number AY390556 and AY274119, respectively) and Paguma SARS-CoV (accession number AY515512) was performed and displayed using CLUSTAL 2.1 and BOXSHADE 3.21, respectively.
T176 3204-3329 Sentence denotes The black background represents the identity while the grey background represents the similarity of the amino acid sequences.
T177 3330-3474 Sentence denotes Orange box indicates the region of signal peptide, while green and blue boxes indicate the core domain and receptor binding domain respectively.
T178 3475-3537 Sentence denotes Sequences of RBD, highlighted in (A) were used for comparison.
T179 3538-3690 Sentence denotes External subdomain variable region of 2019-nCoV HKU-SZ-005b was predicted by comparison of amino acid similarity and published structural analysis [17].
T180 3691-3742 Sentence denotes Purple box indicates the external subdomain region.