PMC:7048229 / 10183-12209 JSONTXT 12 Projects

Annnotations TAB TSV DIC JSON TextAE

Id Subject Object Predicate Lexical cue
T135 0-10 Sentence denotes Discussion
T136 11-124 Sentence denotes Within 1 month of the 2019-nCoV disease outbreak, we rapidly developed molecular and serological detection tools.
T137 125-299 Sentence denotes This is the first molecular and serological study on this virus after the initial identification of 2019-NCoV from 7 patients diagnosed with unidentified viral pneumonia [5].
T138 300-470 Sentence denotes We detected the virus in oral swabs, anal swabs and blood, thus infected patients can potentially shed this pathogen through respiratory, fecal–oral or body fluid routes.
T139 471-605 Sentence denotes In addition, we successfully applied serology test a large population and showed which could greatly improved detection positive rate.
T140 606-729 Sentence denotes We show that the current strategy for the detection of viral RNA in oral swabs used for 2019-nCoV diagnosis is not perfect.
T141 730-825 Sentence denotes The virus may be present in anal swabs or blood of patients when oral swabs detection negative.
T142 826-939 Sentence denotes In SARS-CoV and MERS-CoV infected patients, intestinal infection was observed at later stages of infection [7–9].
T143 940-1059 Sentence denotes However, patients infected with 2019-nCoV may harbour the virus in the intestine at the early or late stage of disease.
T144 1060-1144 Sentence denotes It is also worth to note none of the patients with viremia blood had positive swabs.
T145 1145-1278 Sentence denotes These patients would likely be considered as 2019-nCoV negative through routine surveillance, and thus pose a threat to other people.
T146 1279-1408 Sentence denotes In contrast, we found viral antibodies in near all patients, indicating serology should be considered for 2019-nCoV epidemiology.
T147 1409-1528 Sentence denotes A possible shift from oral positive during early infection to anal swab positive during late infection can be observed.
T148 1529-1675 Sentence denotes This observation implied that we cannot discharge a patient purely based on oral swabs negative, who may still shed the virus by oral–fecal route.
T149 1676-1834 Sentence denotes Above all, we strongly suggest using viral IgM and IgG serological test to confirm an infection, considering the unreliable results from oral swabs detection.
T150 1835-1937 Sentence denotes In summary, we provide a cautionary warning that 2019-nCoV may be transmitted through multiple routes.
T151 1938-2026 Sentence denotes Both molecular and serological tests are needed to definitively confirm a virus carrier.