LitCovid-sentences  

PMC:7036705 / 34-5534 JSONTXT 13 Projects

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Id Subject Object Predicate Lexical cue
T3 0-62 Sentence denotes A novel epidemic is challenging the global health care system.
T4 63-319 Sentence denotes Starting from probably November to December 2019, another Coronavirus entered the arena of human pathogens, to be then defined 2019- nCoV.1 The outbreak of respiratory illness caused by 2019-nCoV was initially detected in Wuhan City, Hubei Province, China.
T5 320-401 Sentence denotes China Republic arranged strong restrictions to limit domestic people circulation.
T6 402-633 Sentence denotes Within days, most European countries and the United States established an unrestricted scientific cooperation to exchange data and information, useful to design a defensive wall against the worldwide spreading of this new epidemic.
T7 634-852 Sentence denotes Spreading is favored by universal access to intercontinental mobility by airplane, and propensity of Chinese people to massively migrate within, but also outside, their subcontinent especially during national holidays.
T8 853-1031 Sentence denotes As of February 5, 2020, the number of confirmed cases was 24,554, with 492 deaths resulting in a crude fatality rate of 2% (https://www.ecdc.europa.eu/en/novelcoronavirus-china).
T9 1032-1156 Sentence denotes Spreading in Europe has been likely slowed down so far by the international coordinated effort, with only 28 cases reported.
T10 1157-1211 Sentence denotes Yet, people are scared by this novel, unknown disease.
T11 1212-1365 Sentence denotes Their daily lifestyle has been affected, with a marked decrease of unnecessary trips abroad, and reduction of events causing massive people accumulation.
T12 1366-1465 Sentence denotes Basic sanitary checks have been enforced on people entering European countries directly from China.
T13 1466-1542 Sentence denotes Questions have been raised even on the opportunity to keep the schools open.
T14 1543-1610 Sentence denotes The fear of unknown diseases is obviously even higher for children.
T15 1611-1795 Sentence denotes As an immediate result, parents are taking their kids to the emergency room of their local hospital more often and in the presence of minimal signs and symptoms of respiratory disease.
T16 1796-1920 Sentence denotes The public health system has arranged a sanitary chain to isolate and quickly screen all possible, but even suspected cases.
T17 1921-2019 Sentence denotes However, this emergency belt might result expensive and hard to be sustained for a very long time.
T18 2020-2267 Sentence denotes In their report of the characteristics of the first 425 cases observed in Wuhan as of January 22, 2020, Li et al. show that none of the patients had less than 15 years of age.2 Is this children-sparing pattern common to other Coronavirus diseases?
T19 2268-2426 Sentence denotes Severe acute respiratory syndrome (SARS) spread in Hong-Kong and then worldwide from March to June 2003, caused by the SARS-associated coronavirus (SARS-CoV).
T20 2427-2626 Sentence denotes Among over 1700 infected individuals, 6.9% were <18 years of age with a case fatality rate of 0%. (Source: e-SARS database, Hospital Authority, Hong Kong Special Administrative Region, data on file).
T21 2627-3034 Sentence denotes In their analysis of 6 case series reporting 135 pediatric SARS patients (80 laboratory-confirmed, 27 probable and 28 suspect) from Canada, Hong Kong, Taiwan and Singapore, Stockman et al. reported that patients 12 years of age or younger had milder disease and were less likely than older children to be admitted to an intensive care unit, receive supplemental oxygen or be treated with methylprednisolone.
T22 3035-3227 Sentence denotes No deaths were reported among children or adolescents with SARS.3 Only one published report of transmission of SARS virus from a pediatric patient was available at the time of writing in 2007.
T23 3228-3416 Sentence denotes In their retrospective analysis of the Middle East Respiratory Syndrome (MERS) spread in 2012, also caused by Corona Virus, Azhar et al. report that only 2% of cases occurred in children.4
T24 3417-3575 Sentence denotes This clearly shows that three different acute respiratory syndromes developed as epidemic in the last decades showed a reduced propensity to involve children.
T25 3576-3781 Sentence denotes Coming to the hottest topic, data from Wuhan show that at an early evaluation, the pediatric population, even in this very-high risk area, appears to be at an unexpectedly low risk to develop the disease.2
T26 3782-3818 Sentence denotes Why may this happen remains unclear.
T27 3819-3933 Sentence denotes Are children absolutely protected from infection or only from the risk to develop the disease following infection?
T28 3934-4033 Sentence denotes Formal demonstration of the ability of 2019-nCov to infect a child has been provided by Chan et al.
T29 4034-4440 Sentence denotes In their report, when screening for 2019-nCov the asymptomatic members of the family of a patient with pneumonia, they documented infection in a child who yet remained asymptomatic.5 Thus, this first and so far unique case shows that infection of children is possible although apparently extremely rare; furthermore, it was not followed by the development of the respiratory disease at the time of writing.
T30 4441-4545 Sentence denotes Persistence of maternal protective immunity extending to the entire pediatric age appears very unlikely.
T31 4546-4611 Sentence denotes No other positively protective effect may be easily hypothesized.
T32 4612-4675 Sentence denotes Are children cross-protected by having met other Coronaviruses?
T33 4676-4878 Sentence denotes Coronaviruses (CoVs) is one of the common viruses that invade the lungs as rhinoviruses, respiratory syncytial virus (RSV), and influenza, which all have an RNA genome and are very frequent in children.
T34 4879-4987 Sentence denotes Innate immune evasion links to the innate immune responses elicited by respiratory and other (RNA) viruses.6
T35 4988-5165 Sentence denotes One explanation could be that pneumonia results from virus-induced immune response causing destruction of pulmonary tissue.7 Such mechanisms could be less effective in children.
T36 5166-5500 Sentence denotes As a bottom-line message, although we do not know how massively 2019-CoV will spread and affect the population worldwide, we may try to reassure the population about the real risk represented by this novel ordeal: their children are apparently at a minimal risk to develop this new disease, and at virtually no risk of a fatal course.