| Id |
Subject |
Object |
Predicate |
Lexical cue |
| T210 |
0-165 |
Sentence |
denotes |
The chief objective of global health efforts against 2019-nCoV remains to effectively quarantine patients and screen individuals who may be infected to limit spread. |
| T211 |
166-211 |
Sentence |
denotes |
That objective should continue going forward. |
| T212 |
212-394 |
Sentence |
denotes |
What is proposed here is an option to at least give infected patients a medication quickly to help alleviate symptoms and prevent death, while vaccine efforts for 2019-nCoV continue. |
| T213 |
395-585 |
Sentence |
denotes |
This could be enabled through ACE2-Fc providing a triple mechanism of action: (1) Treatment of ACE2 deficiency and lung injury, (2) virus neutralization, and (3) immune effector recruitment. |
| T214 |
586-698 |
Sentence |
denotes |
Beyond infected patients, ACE2-Fc could provide passive immunity to healthcare works at risk as another benefit. |
| T215 |
699-905 |
Sentence |
denotes |
Going forward, it is recommended that physicians, scientists, and biotech industry in China and elsewhere pursue manufacturing an ACE2-Fc biologic agent right now, which can immediately advance into trials. |
| T216 |
906-1060 |
Sentence |
denotes |
A variety of different protein expression platforms (CHO, insect, yeast) could be utilized, depending on the particular contract manufacturer’s expertise. |
| T217 |
1061-1271 |
Sentence |
denotes |
Gene therapy could even be considered to make ACE2-Fc from a DNA or mRNA platform, but would have additional risk of uncertain delivery strategies and ultimately may slow down progress toward treating patients. |
