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PMC:7008073 JSONTXT 21 Projects

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Id Subject Object Predicate Lexical cue
T1 0-89 Sentence denotes The First Case of 2019 Novel Coronavirus Pneumonia Imported into Korea from Wuhan, China:
T2 90-147 Sentence denotes Implication for Infection Prevention and Control Measures
T3 149-157 Sentence denotes Abstract
T4 158-300 Sentence denotes In December 2019, a viral pneumonia outbreak caused by a novel betacoronavirus, the 2019 novel coronavirus (2019-nCoV), began in Wuhan, China.
T5 301-430 Sentence denotes We report the epidemiological and clinical features of the first patient with 2019-nCoV pneumonia imported into Korea from Wuhan.
T6 431-670 Sentence denotes This report suggests that in the early phase of 2019-nCoV pneumonia, chest radiography would miss patients with pneumonia and highlights taking travel history is of paramount importance for early detection and isolation of 2019-nCoV cases.
T7 672-1095 Sentence denotes Coronaviruses (CoV) infect birds and several vertebrates including human, and predominantly cause the respiratory tract and gastrointestinal tract infections.1 Six human CoV (HCoV) have been identified, including four endemic (HCoV-OC43, -229E, -NL63, and -HKU1) and two epidemic (SARS-CoV and MERS-CoV) viruses.2 In December 2019, an outbreak of pneumonia of unknown etiology occurred in Wuhan city, Hubei Province, China.
T8 1096-1377 Sentence denotes Most of the patients had a history of visiting the Huanan Seafood Wholesale Market.3 The Chinese scientists isolated a coronavirus from a patient, and phylogenetic analyses of the sequence showed it belongs to a new HCoV, which is designated as 2019 novel coronavirus (2019-nCoV).4
T9 1378-1459 Sentence denotes As of February 1, 2020, China reported 11,821 patients, including 259 fatalities.
T10 1460-1527 Sentence denotes Countries reporting imported cases from China have been increasing.
T11 1528-1993 Sentence denotes Until February 1, 2020, 132 confirmed cases have been reported outside of China in 23 countries; Japan, Republic of Korea, Viet Nam, Singapore, Australia, Malaysia, Cambodia, Philippines, Thailand, Nepal, Sri Lanka, India, USA, Canada, France, Finland, Germany, Italy, Russian Federation, Spain, Sweden, United Kingdom, and United Arab Emirates.5 Here, we report clinical features and radiological findings of a patient with 2019-nCoV pneumonia imported from Wuhan.
T12 1994-2093 Sentence denotes A 35-year-old woman, who lives in Wuhan, China, arrived at the Incheon Airport on January 19, 2020.
T13 2094-2284 Sentence denotes During the quarantine inspection process at the airport, her body temperature was 38.3°C by a thermal scanner; therefore, she was immediately hospitalized in a designated isolation hospital.
T14 2285-2524 Sentence denotes Pan coronavirus conventional polymerase chain reaction (PCR) assay was positive for the throat swab sample, and sequencing of the PCR amplicon showed that the sequence was identical to that of the 2019-nCoV isolated from the Wuhan patient.
T15 2525-2684 Sentence denotes The patient was office accountancy and denied any exposure to a febrile patient, wild animals, or visiting wet markets, including the Sea Food Market in Wuhan.
T16 2685-2807 Sentence denotes One day before entry (January 18, 2020), she developed fever, chill, and myalgia, and she visited a local clinic in Wuhan.
T17 2808-2888 Sentence denotes Chest radiography showed no infiltrates, and she was diagnosed as a common cold.
T18 2889-2954 Sentence denotes She is obese (body mass index, 33.4 kg/m2) but otherwise healthy.
T19 2955-3160 Sentence denotes On admission (January 19, 2020), the physical examination revealed a body temperature of 38.4°C, a respiratory rate of 22 breaths per minute, a pulse of 118 per minute, and a blood pressure of 139/92 mmHg.
T20 3161-3224 Sentence denotes There were no pharyngeal injections, skin rash, and adenopathy.
T21 3225-3462 Sentence denotes The initial chest radiography showed no infiltrations (Fig. 1A), but high-resolution computed tomography (HRCT) on January 21, 2020 (day 4 of illness) showed multiple, ground-glass opacities located in both subpleural spaces (Fig. 1B-E).
T22 3463-3582 Sentence denotes The laboratory tests showed mild changes, including leukopenia, thrombocytopenia, and liver enzyme elevation (Table 1).
T23 3583-3696 Sentence denotes During admission, she developed nasal congestion, cough, sputum, pleuritic chest discomfort, and watery diarrhea.
T24 3697-3912 Sentence denotes On January 21, 2020 (day 4 of illness), she did not complain of shortness of breath, but oxygen supplementation via nasal cannula (3 L/min) was started as a result of decreased arterial oxygen saturation around 91%.
T25 3913-4136 Sentence denotes Her oxygen requirement increased to 6 L/min on January 24, 2020 (day 7 of illness), and chest radiography taken on January 25, 2020 (day 8 of illness) began to show chest infiltrates in the right lower lung field (Fig. 1F).
T26 4137-4275 Sentence denotes After the diagnosis of 2019-nCoV infection was made, lopinavir 400 mg/Ritonavir 100 mg was given from January 21, 2020 (day 4 of illness).
T27 4276-4421 Sentence denotes Fever persisted for ten days with a maximum temperature of 38.9°C on day 7 of illness, and then subsided on January 28, 2019 (day 11 of illness).
T28 4422-4589 Sentence denotes From January 31, 2019 (day 14 of illness), her dyspnea began to improve, reducing oxygen requirement, and the lung lesions also began to diminish in chest radiography.
T29 4590-4722 Sentence denotes The initial symptoms of the patient were fever, myalgia, and sore throat, which are common to any acute respiratory virus infection.
T30 4723-4783 Sentence denotes The only clue to 2019-nCoV infection was her travel history.
T31 4784-4915 Sentence denotes This case highlights that taking travel history is of paramount importance for early detection and isolation of 2019-nCoV patients.
T32 4916-4997 Sentence denotes This patient was detected at the airport by the screening with a thermal scanner.
T33 4998-5065 Sentence denotes Entry screening may help slow the importation of an emerging virus.
T34 5066-5221 Sentence denotes However, it is not a guarantee against the possible importation of it, because it could miss many infected but asymptomatic or mild symptomatic passengers.
T35 5222-5512 Sentence denotes During the pandemic of influenza A (H1N1) in 2009, a study at Auckland International Airport showed the sensitivity of the screening method was only 5.8%.6 Therefore, once the virus is spreading widely and an epidemic already starts, the entry screening will add little value to contain it.
T36 5513-5674 Sentence denotes The real benefit is its advertising effect; it may raise travelers' awareness and educate them about what they should do if they develop symptoms after arriving.
T37 5675-5812 Sentence denotes It is important to note that the patient had pneumonia as early as three days after the symptom onset, although her condition was stable.
T38 5813-6030 Sentence denotes During the first three days, she did not develop any clinical features suggesting pneumonia, such as sputum, pleuritic chest discomfort, hemoptysis, crackles on lung auscultation, and infiltrates in chest radiography.
T39 6031-6122 Sentence denotes If we had not taken an HRCT scan of the lung, we would have missed the pneumonia diagnosis.
T40 6123-6256 Sentence denotes This case highlights that the possibility of 2019-nCoV pneumonia cannot be excluded based only on the clinical clues mentioned above.
T41 6257-6421 Sentence denotes This clinical feature, i.e., mild flu-like symptoms despite pneumonia during the first week of illness (“walking pneumonia”) resembles that of MERS-CoV pneumonia.78
T42 6422-6486 Sentence denotes We do not know the infectious period of 2019-nCoV pneumonia yet.
T43 6487-6626 Sentence denotes We also do not know if patients with mild (or upper respiratory tract infection) symptoms are less infectious than patients with pneumonia.
T44 6627-6754 Sentence denotes What makes the problem more confusing is that we cannot predict who may progress from upper respiratory infection to pneumonia.
T45 6755-6933 Sentence denotes Considering all this, it is safer to do a 2019-nCoV screening test for all symptomatic patients with epidemiological risk than to wait until pneumonia develop and then test them.
T46 6934-7068 Sentence denotes Any clinical criteria for pneumonia would miss substantial number of pneumonia patients, especially during the early phase of illness.
T47 7069-7217 Sentence denotes Infected individual before symptom onset may transmit 2019-nCoV to other people,9 but it remains to be determined how common are such transmissions.
T48 7218-7354 Sentence denotes We urgently need to know the scale of transmission from asymptomatic or mildly symptomatic patients during the early phase of infection.
T49 7356-7372 Sentence denotes Ethics statement
T50 7373-7429 Sentence denotes The images are published under agreement of the patient.
T51 7431-7442 Sentence denotes Disclosure:
T52 7443-7507 Sentence denotes The authors have no potential conflicts of interest to disclose.
T53 7508-7529 Sentence denotes Author Contributions:
T54 7530-7548 Sentence denotes Conceptualization:
T55 7549-7572 Sentence denotes Kim JY, Choe PG, Oh MD.
T56 7573-7587 Sentence denotes Data curation:
T57 7588-7602 Sentence denotes Kim JY, Oh YJ.
T58 7603-7619 Sentence denotes Formal analysis:
T59 7620-7648 Sentence denotes Kim JY, Oh YJ, Oh KJ, Oh MD.
T60 7649-7663 Sentence denotes Investigation:
T61 7664-7711 Sentence denotes Kim JY, Oh KJ, Kim JS, Park SJ, Park JH, Na HK.
T62 7712-7737 Sentence denotes Writing - original draft:
T63 7738-7753 Sentence denotes Choe PG, Oh MD.
T64 7754-7781 Sentence denotes Writing - review & editing:
T65 7782-7805 Sentence denotes Kim JY, Choe PG, Oh MD.
T66 7807-7894 Sentence denotes Fig. 1 Chest imaging of the patient. (A) Chest radiography and HRCT scans of the lung.
T67 7895-8265 Sentence denotes Chest radiography taken on January 21, 2020 (3 days after the symptom onset) revealed no pulmonary infiltrates. (B-E) However, the HRCT scans taken on the same day showed bilateral, multiple, ground glass opacities. (F) The chest radiography taken on January 25, 2020 (7 days after the symptom onset) began to show the pulmonary infiltrates in the left lower lung field.
T68 8266-8309 Sentence denotes HRCT = high-resolution computed tomography.
T69 8310-8366 Sentence denotes The images are published under agreement of the patient.
T70 8367-8407 Sentence denotes Table 1 Laboratory data for the patient
T71 8408-8545 Sentence denotes Day White blood cells, cells/mm3 Hemoglobin, g/dL Platelets, cells/mm3 Creatinine, mg/dL Albumin, g/dL AST, U/L ALT, U/L LDH, U/L
T72 8546-8596 Sentence denotes January 19 5,600 13.7 193 0.82 4.6 60 70 -
T73 8597-8647 Sentence denotes January 20 4,450 13.4 180 0.71 4.4 43 57 -
T74 8648-8698 Sentence denotes January 21 3,610 12.6 155 0.66 4.1 38 46 -
T75 8699-8751 Sentence denotes January 22 3,160 13.1 166 0.78 4.4 38 46 439
T76 8752-8804 Sentence denotes January 23 3,080 12.4 134 0.71 4.0 41 43 472
T77 8805-8857 Sentence denotes January 24 3,320 12.1 127 0.71 4.0 38 40 486
T78 8858-8910 Sentence denotes January 25 3,240 11.4 126 0.76 3.8 34 34 521
T79 8911-8963 Sentence denotes January 26 3,530 11.1 139 0.66 3.7 26 28 528
T80 8964-9016 Sentence denotes January 27 3,710 11.0 160 0.63 3.8 26 26 553
T81 9017-9069 Sentence denotes January 28 3,900 11.4 210 0.63 3.9 26 26 561
T82 9070-9122 Sentence denotes January 29 4,900 11.1 235 0.61 3.8 21 23 497
T83 9123-9213 Sentence denotes AST = aspartate aminotransferase, ALT = alanine transaminase, LDH = lactate dehydrogenase.