Id |
Subject |
Object |
Predicate |
Lexical cue |
T15 |
0-12 |
Sentence |
denotes |
Introduction |
T16 |
13-203 |
Sentence |
denotes |
According to the World Health Organization (WHO), the WHO China Country Office was informed of cases of pneumonia of unknown aetiology in Wuhan City, Hubei Province, on 31 December 2019 [1]. |
T17 |
204-335 |
Sentence |
denotes |
A novel coronavirus currently termed 2019-nCoV was officially announced as the causative agent by Chinese authorities on 7 January. |
T18 |
336-684 |
Sentence |
denotes |
A viral genome sequence was released for immediate public health support via the community online resource virological.org on 10 January (Wuhan-Hu-1, GenBank accession number MN908947 [2]), followed by four other genomes deposited on 12 January in the viral sequence database curated by the Global Initiative on Sharing All Influenza Data (GISAID). |
T19 |
685-924 |
Sentence |
denotes |
The genome sequences suggest presence of a virus closely related to the members of a viral species termed severe acute respiratory syndrome (SARS)-related CoV, a species defined by the agent of the 2002/03 outbreak of SARS in humans [3,4]. |
T20 |
925-1033 |
Sentence |
denotes |
The species also comprises a large number of viruses mostly detected in rhinolophid bats in Asia and Europe. |
T21 |
1034-1124 |
Sentence |
denotes |
As at 20 January 2019, 282 laboratory-confirmed human cases have been notified to WHO [5]. |
T22 |
1125-1272 |
Sentence |
denotes |
Confirmed cases in travellers from Wuhan were announced on 13 and 17 January in Thailand as well as on 15 January in Japan and 19 January in Korea. |
T23 |
1273-1435 |
Sentence |
denotes |
The extent of human-to-human transmission of 2019-nCoV is unclear at the time of writing of this report but there is evidence of some human-to-human transmission. |
T24 |
1436-1541 |
Sentence |
denotes |
Among the foremost priorities to facilitate public health interventions is reliable laboratory diagnosis. |
T25 |
1542-1655 |
Sentence |
denotes |
In acute respiratory infection, RT-PCR is routinely used to detect causative viruses from respiratory secretions. |
T26 |
1656-1907 |
Sentence |
denotes |
We have previously demonstrated the feasibility of introducing robust detection technology based on real-time RT-PCR in public health laboratories during international health emergencies by coordination between public and academic laboratories [6-12]. |
T27 |
1908-2053 |
Sentence |
denotes |
In all of these situations, virus isolates were available as the primary substrate for establishing and controlling assays and assay performance. |
T28 |
2054-2215 |
Sentence |
denotes |
In the present case of 2019-nCoV, virus isolates or samples from infected patients have so far not become available to the international public health community. |
T29 |
2216-2421 |
Sentence |
denotes |
We report here on the establishment and validation of a diagnostic workflow for 2019-nCoV screening and specific confirmation, designed in absence of available virus isolates or original patient specimens. |
T30 |
2422-2570 |
Sentence |
denotes |
Design and validation were enabled by the close genetic relatedness to the 2003 SARS-CoV, and aided by the use of synthetic nucleic acid technology. |