LitCovid-sentences-v1  

PubMed:32213337 JSONTXT 12 Projects

Annnotations TAB TSV DIC JSON TextAE

Id Subject Object Predicate Lexical cue
TextSentencer_T1 0-165 Sentence denotes Temporal profiles of viral load in posterior oropharyngeal saliva samples and serum antibody responses during infection by SARS-CoV-2: an observational cohort study.
TextSentencer_T2 166-177 Sentence denotes BACKGROUND:
TextSentencer_T3 178-263 Sentence denotes Coronavirus disease 2019 (COVID-19) causes severe community and nosocomial outbreaks.
TextSentencer_T4 264-457 Sentence denotes Comprehensive data for serial respiratory viral load and serum antibody responses from patients infected with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) are not yet available.
TextSentencer_T5 458-670 Sentence denotes Nasopharyngeal and throat swabs are usually obtained for serial viral load monitoring of respiratory infections but gathering these specimens can cause discomfort for patients and put health-care workers at risk.
TextSentencer_T6 671-855 Sentence denotes We aimed to ascertain the serial respiratory viral load of SARS-CoV-2 in posterior oropharyngeal (deep throat) saliva samples from patients with COVID-19, and serum antibody responses.
TextSentencer_T7 856-864 Sentence denotes METHODS:
TextSentencer_T8 865-917 Sentence denotes We did a cohort study at two hospitals in Hong Kong.
TextSentencer_T9 918-974 Sentence denotes We included patients with laboratory-confirmed COVID-19.
TextSentencer_T10 975-1061 Sentence denotes We obtained samples of blood, urine, posterior oropharyngeal saliva, and rectal swabs.
TextSentencer_T11 1062-1148 Sentence denotes Serial viral load was ascertained by reverse transcriptase quantitative PCR (RT-qPCR).
TextSentencer_T12 1149-1296 Sentence denotes Antibody levels against the SARS-CoV-2 internal nucleoprotein (NP) and surface spike protein receptor binding domain (RBD) were measured using EIA.
TextSentencer_T13 1297-1386 Sentence denotes Whole-genome sequencing was done to identify possible mutations arising during infection.
TextSentencer_T14 1387-1396 Sentence denotes FINDINGS:
TextSentencer_T15 1397-1539 Sentence denotes Between Jan 22, 2020, and Feb 12, 2020, 30 patients were screened for inclusion, of whom 23 were included (median age 62 years [range 37-75]).
TextSentencer_T16 1540-1685 Sentence denotes The median viral load in posterior oropharyngeal saliva or other respiratory specimens at presentation was 5·2 log10 copies per mL (IQR 4·1-7·0).
TextSentencer_T17 1686-1842 Sentence denotes Salivary viral load was highest during the first week after symptom onset and subsequently declined with time (slope -0·15, 95% CI -0·19 to -0·11; R2=0·71).
TextSentencer_T18 1843-1910 Sentence denotes In one patient, viral RNA was detected 25 days after symptom onset.
TextSentencer_T19 1911-2007 Sentence denotes Older age was correlated with higher viral load (Spearman's ρ=0·48, 95% CI 0·074-0·75; p=0·020).
TextSentencer_T20 2008-2239 Sentence denotes For 16 patients with serum samples available 14 days or longer after symptom onset, rates of seropositivity were 94% for anti-NP IgG (n=15), 88% for anti-NP IgM (n=14), 100% for anti-RBD IgG (n=16), and 94% for anti-RBD IgM (n=15).
TextSentencer_T21 2240-2345 Sentence denotes Anti-SARS-CoV-2-NP or anti-SARS-CoV-2-RBD IgG levels correlated with virus neutralisation titre (R2>0·9).
TextSentencer_T22 2346-2398 Sentence denotes No genome mutations were detected on serial samples.
TextSentencer_T23 2399-2414 Sentence denotes INTERPRETATION:
TextSentencer_T24 2415-2534 Sentence denotes Posterior oropharyngeal saliva samples are a non-invasive specimen more acceptable to patients and health-care workers.
TextSentencer_T25 2535-2713 Sentence denotes Unlike severe acute respiratory syndrome, patients with COVID-19 had the highest viral load near presentation, which could account for the fast-spreading nature of this epidemic.
TextSentencer_T26 2714-2877 Sentence denotes This finding emphasises the importance of stringent infection control and early use of potent antiviral agents, alone or in combination, for high-risk individuals.
TextSentencer_T27 2878-2933 Sentence denotes Serological assay can complement RT-qPCR for diagnosis.
TextSentencer_T28 2934-2942 Sentence denotes FUNDING:
TextSentencer_T29 2943-3107 Sentence denotes Richard and Carol Yu, May Tam Mak Mei Yin, The Shaw Foundation Hong Kong, Michael Tong, Marina Lee, Government Consultancy Service, and Sanming Project of Medicine.