| Id |
Subject |
Object |
Predicate |
Lexical cue |
| T3 |
0-177 |
Sentence |
denotes |
Severe acute respiratory syndrome (SARS) and Middle East respiratory syndrome (MERS) coronaviruses (CoVs) are zoonotic pathogens with high fatality rates and pandemic potential. |
| T4 |
178-302 |
Sentence |
denotes |
Vaccine development focuses on the principal target of the neutralizing humoral immune response, the spike (S) glycoprotein. |
| T5 |
303-426 |
Sentence |
denotes |
Coronavirus S proteins are extensively glycosylated, encoding around 66–87 N-linked glycosylation sites per trimeric spike. |
| T6 |
427-600 |
Sentence |
denotes |
Here, we reveal a specific area of high glycan density on MERS S that results in the formation of oligomannose-type glycan clusters, which were absent on SARS and HKU1 CoVs. |
| T7 |
601-864 |
Sentence |
denotes |
We provide a comparison of the global glycan density of coronavirus spikes with other viral proteins including HIV-1 envelope, Lassa virus glycoprotein complex, and influenza hemagglutinin, where glycosylation plays a known role in shielding immunogenic epitopes. |
| T8 |
865-1074 |
Sentence |
denotes |
Overall, our data reveal how organisation of glycosylation across class I viral fusion proteins influence not only individual glycan compositions but also the immunological pressure across the protein surface. |
