| Id |
Subject |
Object |
Predicate |
Lexical cue |
| T137 |
0-146 |
Sentence |
denotes |
More topically, it is interesting to note the conservation of N-linked glycosylation sites on S proteins from the SARS-CoV-2 and SARS (SI Fig. 6). |
| T138 |
147-269 |
Sentence |
denotes |
SARS-CoV-2 possesses a total of 22 N-linked glycan sites compared with 23 on SARS, with 18 of these sites being in common. |
| T139 |
270-407 |
Sentence |
denotes |
As such, it is likely that these glycans on this novel coronavirus would shield similar immunogenic epitopes that are observed on SARS S. |
| T140 |
408-586 |
Sentence |
denotes |
As expected, most of the differences between the two viruses are observed on the S1 subunit, due to its amenability to substitutions while still remaining functionally competent. |
| T141 |
587-750 |
Sentence |
denotes |
Furthermore, likely targets for the majority of antibodies targeting the spike are located on S1, resulting in greater levels of immune pressure upon this subunit. |
| T142 |
751-977 |
Sentence |
denotes |
This notion is further reflected in terms of glycosylation, with all of the glycan sites conserved on the S2 subunit between SARS and SARS-CoV-2, whereas the S1 subunit exhibits glycan site additions and deletions (SI Fig. 7). |
| T143 |
978-1195 |
Sentence |
denotes |
Bioinformatic analysis of current SARS-CoV-2 spike genes (n = 566 as of 17 March 2020) from nextstrain61 (https://nextstrain.org/ncov) revealed low sequence diversity and no changes in glycosylation sites (SI Fig. 8). |
