LitCovid-sample-sentences  

PMC:7205724 / 5311-7092 JSONTXT 24 Projects

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Id Subject Object Predicate Lexical cue
T50 0-20 Sentence denotes 3.1.2 Glycosylation
T51 21-191 Sentence denotes Glycosylation and its related products, i.e., glycans, introduce changes to the viral envelope that make the virus fitted for interaction with the host cell membrane [5].
T52 192-289 Sentence denotes Generally, glycans are oligosaccharides linked to the dense decoration of the spike glycoprotein.
T53 290-450 Sentence denotes In particular, these oligosaccharides have shown to influence the folding of the S protein and proteolytic process so that they facilitate the virus cell entry.
T54 451-567 Sentence denotes Moreover, a virus with the glycosylated glycoprotein gains an extra feature for an escape from the immune responses.
T55 568-624 Sentence denotes Therefore, glycans are a good target for vaccine design.
T56 625-685 Sentence denotes Two main types of glycans are N-linked and O-linked glycans.
T57 686-723 Sentence denotes Both are released from glycoproteins.
T58 724-829 Sentence denotes Whereas enzymes fulfill the construction of N-glycans, chemical methods perform the release of O-glycans.
T59 830-1007 Sentence denotes N-glycans are linked to the amino acid asparagine (Asn) residues (Asn-any amino acids except for proline- Ser or Thr) utilizing an N-glycosidic bond, mostly N-acetylglucosamine.
T60 1008-1145 Sentence denotes O-glycans are attached to the amino acid serine (Ser) and threonine (Thr) residues by the addition of an N-acetyl galactosamine (GalNAc).
T61 1146-1315 Sentence denotes For example, N-glycans exist in Hendra virus, SARS-CoV, influenza virus, hepatitis virus, HIV-1, and West Nile virus [6], and O-glycans have occurred in the Ebola virus.
T62 1316-1431 Sentence denotes The 2019-nCoV S protein includes 13 and 9N-linked glycosylation sequons in the S1 and S2 subunit, respectively [3].
T63 1432-1557 Sentence denotes All of these have previously occurred in the SARS-CoV S glycoprotein, except for four-linked glycosylation sequons in the S1.
T64 1558-1781 Sentence denotes Also, due to the existence of an amino acid proline in the polybasic cleavage site, which makes the inserted sequence PRRA, there are three O-linked glycans introduced to the 2019-nCoV RBD residues S673, T678, and S686 [7].