PubMed:33175425 JSONTXT 19 Projects

COVID-19 lessons from the dish: Dissecting CNS manifestations through brain organoids. SARS-CoV-2 is increasingly understood as a systemic disease with pathogenic manifestations beyond the respiratory tract. Recent work by Ramani et al (2020) dissects the cellular and molecular mechanisms of COVID-19's neurotrophic properties, using viral exposure of human brain organoids. Their findings highlight neurons as primary target of cerebral SARS-CoV-2 infection and uncover its Tau-related neurotoxicity.