LitCoin-sentences  

PubMed:27860244 JSONTXT 27 Projects

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Id Subject Object Predicate Lexical cue
T1 0-131 Sentence denotes Role of protein arginine methyltransferase 5 in inflammation and migration of fibroblast-like synoviocytes in rheumatoid arthritis.
T2 132-353 Sentence denotes To probe the role of protein arginine methyltransferase 5 (PRMT5) in regulating inflammation, cell proliferation, migration and invasion of fibroblast-like synoviocytes (FLSs) from patients with rheumatoid arthritis (RA).
T3 354-448 Sentence denotes FLSs were separated from synovial tissues (STs) from patients with RA and osteoarthritis (OA).
T4 449-570 Sentence denotes An inhibitor of PRMT5 (EPZ015666) and short interference RNA (siRNA) against PRMT5 were used to inhibit PRMT5 expression.
T5 571-646 Sentence denotes The standard of protein was measured by Western blot or immunofluorescence.
T6 647-829 Sentence denotes The excretion and genetic expression of inflammatory factors were, respectively, estimated by enzyme-linked immunosorbent assay (ELISA) and real-time polymerase chain reaction (PCR).
T7 830-900 Sentence denotes Migration and invasion in vitro were detected by Boyden chamber assay.
T8 901-955 Sentence denotes FLSs proliferation was detected by BrdU incorporation.
T9 956-1025 Sentence denotes Increased PRMT5 was discovered in STs and FLSs from patients with RA.
T10 1026-1110 Sentence denotes In RA FLSs, the level of PRMT5 was up-regulated by stimulation with IL-1β and TNF-α.
T11 1111-1236 Sentence denotes Inhibition of PRMT5 by EPZ015666 and siRNA-mediated knockdown reduced IL-6 and IL-8 production, and proliferation of RA FLSs.
T12 1237-1323 Sentence denotes In addition, inhibition of PRMT5 decreased in vitro migration and invasion of RA FLSs.
T13 1324-1467 Sentence denotes Furthermore, EPZ015666 restrained the phosphorylation of IκB kinaseβ and IκBα, as well as nucleus transsituation of p65 as well as AKT in FLSs.
T14 1468-1627 Sentence denotes PRMT5 regulated the production of inflammatory factors, cell proliferation, migration and invasion of RA FLS, which was mediated by the NF-κB and AKT pathways.
T15 1628-1753 Sentence denotes Our data suggested that targeting PRMT5 to prevent synovial inflammation and destruction might be a promising therapy for RA.