LitCoin-sentences  

PubMed:22711886 JSONTXT 27 Projects

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Id Subject Object Predicate Lexical cue
T1 0-132 Sentence denotes TNFR-associated factor 2 deficiency in B lymphocytes predisposes to chronic lymphocytic leukemia/small lymphocytic lymphoma in mice.
T2 133-445 Sentence denotes We have previously shown that transgenic (tg) mice expressing in B lymphocytes both BCL-2 and a TNFR-associated factor 2 (TRAF2) mutant lacking the really interesting new gene and zinc finger domains (TRAF2DN) develop small lymphocytic lymphoma and chronic lymphocytic leukemia with high incidence (Zapata et al.
T3 446-451 Sentence denotes 2004.
T4 452-457 Sentence denotes Proc.
T5 458-462 Sentence denotes Nat.
T6 463-468 Sentence denotes Acad.
T7 469-473 Sentence denotes Sci.
T8 474-482 Sentence denotes USA 101:
T9 483-496 Sentence denotes 16600-16605).
T10 497-708 Sentence denotes Further analysis of the expression of TRAF2 and TRAF2DN in purified B cells demonstrated that expression of both endogenous TRAF2 and tg TRAF2DN was negligible in Traf2DN-tg B cells compared with wild-type mice.
T11 709-832 Sentence denotes This was the result of proteasome-dependent degradation, and rendered TRAF2DN B cells as bona fide TRAF2-deficient B cells.
T12 833-989 Sentence denotes Similar to B cells with targeted Traf2 deletion, Traf2DN-tg mice show expanded marginal zone B cell population and have constitutive p100 NF-κB2 processing.
T13 990-1211 Sentence denotes Also, TRAF3, X-linked inhibitor of apoptosis, and Bcl-X(L) expression levels were increased, whereas cellular inhibitors of apoptosis 1 and 2 levels were drastically reduced compared with those found in wild-type B cells.
T14 1212-1361 Sentence denotes Moreover, consistent with previous results, we also show that TRAF2 was required for efficient JNK and ERK activation in response to CD40 engagement.
T15 1362-1438 Sentence denotes However, TRAF2 was deleterious for BCR-mediated activation of these kinases.
T16 1439-1574 Sentence denotes In contrast, TRAF2 deficiency had no effect on CD40-mediated p38 MAPK activation but significantly reduced BCR-mediated p38 activation.
T17 1575-1747 Sentence denotes Finally, we further confirm that TRAF2 was required for CD40-mediated proliferation, but its absence relieved B cells of the need for B cell activating factor for survival.
T18 1748-2102 Sentence denotes Altogether, our results suggest that TRAF2 deficiency cooperates with BCL-2 in promoting chronic lymphocytic leukemia/small lymphocytic lymphoma in mice, possibly by specifically enforcing marginal zone B cell accumulation, increasing X-linked inhibitor of apoptosis expression, and rendering B cells independent of B cell activating factor for survival.