LitCoin-sentences  

PubMed:19306381 JSONTXT 24 Projects

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Id Subject Object Predicate Lexical cue
T1 0-139 Sentence denotes Neuregulin-1 beta and neuregulin-1 alpha differentially affect the migration and invasion of malignant peripheral nerve sheath tumor cells.
T2 140-268 Sentence denotes Malignant peripheral nerve sheath tumors (MPNSTs) are the most common malignancy associated with neurofibromatosis Type 1 (NF1).
T3 269-406 Sentence denotes These Schwann cell lineage-derived sarcomas aggressively invade adjacent nerve and soft tissue, frequently precluding surgical resection.
T4 407-482 Sentence denotes Little is known regarding the mechanisms underlying this invasive behavior.
T5 483-689 Sentence denotes We have shown that MPNSTs express neuregulin-1 (NRG-1) beta isoforms, which promote Schwann cell migration during development, and NRG-1 alpha isoforms, whose effects on Schwann cells are poorly understood.
T6 690-927 Sentence denotes Hypothesizing that NRG-1 beta and/or NRG-1 alpha promote MPNST invasion, we found that NRG-1 beta promoted MPNST migration in a substrate-specific manner, markedly enhancing migration on laminin but not on collagen type I or fibronectin.
T7 928-1168 Sentence denotes The NRG-1 receptors erbB3 and erbB4 were present in MPNST invadopodia (processes mediating invasion), partially colocalized with focal adhesion kinase and the laminin receptor beta(1)-integrin and coimmunoprecipitated with beta(1)-integrin.
T8 1169-1348 Sentence denotes NRG-1 beta stimulated human and murine MPNST cell migration and invasion in a concentration-dependent manner in three-dimensional migration assays, acting as a chemotactic factor.
T9 1349-1508 Sentence denotes Both baseline and NRG-1 beta-induced migration were erbB-dependent and required the action of MEK 1/2, SAPK/JNK, PI-3 kinase, Src family kinases and ROCK-I/II.
T10 1509-1636 Sentence denotes In contrast, NRG-1 alpha had no effect on the migration and invasion of some MPNST lines and inhibited the migration of others.
T11 1637-1877 Sentence denotes While NRG-1 beta potently and persistently activated Erk 1/2, SAPK/JNK, Akt and Src family kinases, NRG-1 alpha did not activate Akt and activated these other kinases with kinetics distinct from those evident in NRG-1 beta-stimulated cells.
T12 1878-2015 Sentence denotes These findings suggest that NRG-1 beta enhances MPNST migration and that NRG-1 beta and NRG-1 alpha differentially modulate this process.