LitCoin-sentences  

PubMed:16506214 JSONTXT 28 Projects

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Id Subject Object Predicate Lexical cue
T1 0-82 Sentence denotes Genetic variation in the COX-2 gene and the association with prostate cancer risk.
T2 83-161 Sentence denotes COX-2 is a key enzyme in the conversion of arachidonic acid to prostaglandins.
T3 162-279 Sentence denotes The prostaglandins produced by COX-2 are involved in inflammation and pain response in different tissues in the body.
T4 280-496 Sentence denotes Accumulating evidence from epidemiologic studies, chemical carcinogen-induced rodent models and clinical trials indicate that COX-2 plays a role in human carcinogenesis and is overexpressed in prostate cancer tissue.
T5 497-594 Sentence denotes We examined whether sequence variants in the COX-2 gene are associated with prostate cancer risk.
T6 595-728 Sentence denotes We analyzed a large population-based case-control study, cancer prostate in Sweden (CAPS) consisting of 1,378 cases and 782 controls.
T7 729-851 Sentence denotes We evaluated 16 single nucleotide polymorphisms (SNPs) spanning the entire COX-2 gene in 94 subjects of the control group.
T8 852-1044 Sentence denotes Five SNPs had a minor allele frequency of more than 5% in our study population and these were genotyped in all case patients and control subjects and gene-specific haplotypes were constructed.
T9 1045-1276 Sentence denotes A statistically significant difference in allele frequency between cases and controls was observed for 2 of the SNPs (+3100 T/G and +8365 C/T), with an odds ratio of 0.78 (95% CI=0.64-0.96) and 0.65 (95% CI=0.45-0.94) respectively.
T10 1277-1529 Sentence denotes In the haplotype analysis, 1 haplotype carrying the variant allele from both +3100 T/G and +8365 C/T, with a population frequency of 3%, was also significantly associated with decreased risk of prostate cancer (p=0.036, global simulated p-value=0.046).
T11 1530-1710 Sentence denotes This study supports the hypothesis that inflammation is involved in prostate carcinogenesis and that sequence variation within the COX-2 gene influence the risk of prostate cancer.