LitCoin-sentences  

PubMed:15820770 JSONTXT 26 Projects

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Id Subject Object Predicate Lexical cue
T1 0-100 Sentence denotes Vitamin D-binding protein gene polymorphism association with IA-2 autoantibodies in type 1 diabetes.
T2 101-112 Sentence denotes BACKGROUND:
T3 113-239 Sentence denotes Vitamin D-binding protein (DBP) is the main systemic transporter of 1.25(OH)2D3 and is essential for its cellular endocytosis.
T4 240-497 Sentence denotes There are two known polymorphisms in exon 11 of the DBP gene resulting in amino acid variants: GAT-->GAG substitution replaces aspartic acid by glutamic acid in codon 416; and ACG-->AAG substitution in codon 420 leads to an exchange of threonine for lysine.
T5 498-569 Sentence denotes These DBP variants lead to differences in the affinity for 1.25(OH)2D3.
T6 570-668 Sentence denotes Correlations between DBP alleles and type 1 diabetes have been described in different populations.
T7 669-804 Sentence denotes Therefore, we investigated the polymorphism in codon 416 of the DBP gene for an association with autoimmune markers of type 1 diabetes.
T8 805-824 Sentence denotes DESIGN AND METHODS:
T9 825-871 Sentence denotes The present analysis was a case control study.
T10 872-983 Sentence denotes 110 patients, 68 controls, and 115 first-degree relatives were genotyped for the DBP polymorphism in codon 416.
T11 984-1088 Sentence denotes DNA typing of DBP locus was performed by the PCR-restriction fragment length polymorphism method (RFLP).
T12 1089-1097 Sentence denotes RESULTS:
T13 1098-1234 Sentence denotes The frequencies of the Asp/Glu and Glu/Glu were significantly increased in diabetic subjects with detectable IA-2 antibodies (P < 0.01).
T14 1235-1357 Sentence denotes On the contrary, the DBP Glu-containing genotype was not accompanied by differences in the prevalence of GAD65 antibodies.
T15 1358-1467 Sentence denotes These finding supports a role of the vitamin D endocrine system in the autoimmune process of type 1 diabetes.