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PubMed:28777492 JSONTXT 25 Projects

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Id Subject Object Predicate Lexical cue
T1 0-114 Sentence denotes Gankyrin induces STAT3 activation in tumour microenvironment and sorafenib resistance in hepatocellular carcinoma.
T1 0-114 Sentence denotes Gankyrin induces STAT3 activation in tumour microenvironment and sorafenib resistance in hepatocellular carcinoma.
T2 115-203 Sentence denotes Most hepatocellular carcinomas (HCCs) develop as a result of chronic liver inflammation.
T2 115-203 Sentence denotes Most hepatocellular carcinomas (HCCs) develop as a result of chronic liver inflammation.
T3 204-313 Sentence denotes We have shown that the oncoprotein gankyrin is critical for inflammation-induced tumourigenesis in the colon.
T3 204-313 Sentence denotes We have shown that the oncoprotein gankyrin is critical for inflammation-induced tumourigenesis in the colon.
T4 314-414 Sentence denotes Although the in vitro function of gankyrin is well known, its role in vivo remains to be elucidated.
T4 314-414 Sentence denotes Although the in vitro function of gankyrin is well known, its role in vivo remains to be elucidated.
T5 415-668 Sentence denotes We investigated the effect of gankyrin in tumour microenvironment of mice with liver parenchymal cell-specific gankyrin ablation (Alb-Cre;gankyrin(f/f) ) and gankyrin deletion both in liver parenchymal and non-parenchymal cells (Mx1-Cre;gankyrin(f/f) ).
T5 415-668 Sentence denotes We investigated the effect of gankyrin in tumour microenvironment of mice with liver parenchymal cell-specific gankyrin ablation (Alb-Cre;gankyrin(f/f) ) and gankyrin deletion both in liver parenchymal and non-parenchymal cells (Mx1-Cre;gankyrin(f/f) ).
T6 669-721 Sentence denotes Gankyrin upregulates VEGF expression in tumor cells.
T6 669-721 Sentence denotes Gankyrin upregulates VEGF expression in tumor cells.
T7 722-968 Sentence denotes Gankyrin binds to Src homology 2 domain-containing protein tyrosine phosphatase-1 (SHP-1), mainly expressed in liver non-parenchymal cells, resulting in phosphorylation and activation of signal transducer and activator of transcription 3 (STAT3).
T7 722-968 Sentence denotes Gankyrin binds to Src homology 2 domain-containing protein tyrosine phosphatase-1 (SHP-1), mainly expressed in liver non-parenchymal cells, resulting in phosphorylation and activation of signal transducer and activator of transcription 3 (STAT3).
T8 969-1238 Sentence denotes Gankyrin deficiency in non-parenchymal cells, but not in parenchymal cells, reduced STAT3 activity, interleukin (IL)-6 production, and cancer stem cell marker (Bmi1 and epithelial cell adhesion molecule [EpCAM]) expression, leading to attenuated tumourigenic potential.
T8 969-1238 Sentence denotes Gankyrin deficiency in non-parenchymal cells, but not in parenchymal cells, reduced STAT3 activity, interleukin (IL)-6 production, and cancer stem cell marker (Bmi1 and epithelial cell adhesion molecule [EpCAM]) expression, leading to attenuated tumourigenic potential.
T9 1239-1308 Sentence denotes Chronic inflammation enhances gankyrin expression in the human liver.
T9 1239-1308 Sentence denotes Chronic inflammation enhances gankyrin expression in the human liver.
T10 1309-1467 Sentence denotes Gankyrin expression in the tumour microenvironment is negatively correlated with progression-free survival in patients undergoing sorafenib treatment for HCC.
T10 1309-1467 Sentence denotes Gankyrin expression in the tumour microenvironment is negatively correlated with progression-free survival in patients undergoing sorafenib treatment for HCC.
T11 1468-1651 Sentence denotes Thus, gankyrin appears to play a critical oncogenic function in tumour microenvironment and may be a potential target for developing therapeutic and preventive strategies against HCC.
T11 1468-1651 Sentence denotes Thus, gankyrin appears to play a critical oncogenic function in tumour microenvironment and may be a potential target for developing therapeutic and preventive strategies against HCC.
T12 1652-1691 Sentence denotes This article is protected by copyright.
T12 1652-1691 Sentence denotes This article is protected by copyright.
T13 1692-1712 Sentence denotes All rights reserved.
T13 1692-1712 Sentence denotes All rights reserved.