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PubMed:27149136 JSONTXT 9 Projects

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Id Subject Object Predicate Lexical cue
T1 0-27 Sentence denotes Paraneoplastic Scleroderma:
T1 0-27 Sentence denotes Paraneoplastic Scleroderma:
T2 28-48 Sentence denotes Are There Any Clues?
T2 28-48 Sentence denotes Are There Any Clues?
T3 49-152 Sentence denotes Dear Editor, Scleroderma associated with neoplasia is rare, with only a small number of cases reported.
T3 49-152 Sentence denotes Dear Editor, Scleroderma associated with neoplasia is rare, with only a small number of cases reported.
T4 153-234 Sentence denotes We describe 4 patients with paraneoplastic scleroderma who were treated at the I.
T4 153-234 Sentence denotes We describe 4 patients with paraneoplastic scleroderma who were treated at the I.
T5 235-328 Sentence denotes Department of Dermatovenereology, St. Anna Hospital, during the period between 2004 and 2014.
T5 235-328 Sentence denotes Department of Dermatovenereology, St. Anna Hospital, during the period between 2004 and 2014.
T6 329-473 Sentence denotes The patients were diagnosed with cholangiogenic carcinoma, endometrial carcinoma, prostatic adenocarcinoma, and adenoma of the suprarenal gland.
T6 329-473 Sentence denotes The patients were diagnosed with cholangiogenic carcinoma, endometrial carcinoma, prostatic adenocarcinoma, and adenoma of the suprarenal gland.
T7 474-736 Sentence denotes In the case of concurrent scleroderma and tumor, four situations may occur: they can develop independently of each other; scleroderma may be induced by the tumor; the tumor can develop in the scleroderma; or the tumor can be induced by immunosuppressive therapy.
T7 474-736 Sentence denotes In the case of concurrent scleroderma and tumor, four situations may occur: they can develop independently of each other; scleroderma may be induced by the tumor; the tumor can develop in the scleroderma; or the tumor can be induced by immunosuppressive therapy.
T8 737-950 Sentence denotes Sclerotization of the skin was described in association with lung cancer, carcinoid, plasma cell dyscrasia, cancer of the ovary, cervix, breast, esophagus, stomach, nasopharynx, melanoma, and sarcoma (1,2,5,7,10).
T8 737-950 Sentence denotes Sclerotization of the skin was described in association with lung cancer, carcinoid, plasma cell dyscrasia, cancer of the ovary, cervix, breast, esophagus, stomach, nasopharynx, melanoma, and sarcoma (1,2,5,7,10).
T9 951-1043 Sentence denotes Symptoms may be induced by substances secreted by the tumor (hormones, cytokines, etc.) (9).
T9 951-1043 Sentence denotes Symptoms may be induced by substances secreted by the tumor (hormones, cytokines, etc.) (9).
T10 1044-1110 Sentence denotes Tumorous cells further induce cytotoxic and autoantibody response.
T10 1044-1110 Sentence denotes Tumorous cells further induce cytotoxic and autoantibody response.
T11 1111-1259 Sentence denotes Scleroderma is characterized by immunological dysregulation, vasculopathy, and hyperproduction of the extracellular matrix by activated fibroblasts.
T11 1111-1259 Sentence denotes Scleroderma is characterized by immunological dysregulation, vasculopathy, and hyperproduction of the extracellular matrix by activated fibroblasts.
T12 1260-1547 Sentence denotes Endothelial, inflammatory, and mesenchymal cells produce cytokines, chemokines, and growth factors e.g. Interleukin-1 (IL1), Interleukin-6 (IL6), tumor necrosis factor alpha (TNF α), collagen alpha 1, connective tissue growth factor (CTGF) (3), and basic fibroblast growth factor (bFGF).
T12 1260-1547 Sentence denotes Endothelial, inflammatory, and mesenchymal cells produce cytokines, chemokines, and growth factors e.g. Interleukin-1 (IL1), Interleukin-6 (IL6), tumor necrosis factor alpha (TNF α), collagen alpha 1, connective tissue growth factor (CTGF) (3), and basic fibroblast growth factor (bFGF).
T13 1548-1602 Sentence denotes This factor is also produced by lung cancer cells (4).
T13 1548-1602 Sentence denotes This factor is also produced by lung cancer cells (4).
T14 1603-1681 Sentence denotes The clinical picture of scleroderma and paraneoplastic scleroderma is similar.
T14 1603-1681 Sentence denotes The clinical picture of scleroderma and paraneoplastic scleroderma is similar.
T15 1682-1756 Sentence denotes Diffuse thickening of the skin and/or sclerodermatous plaques can be seen.
T15 1682-1756 Sentence denotes Diffuse thickening of the skin and/or sclerodermatous plaques can be seen.
T16 1757-1813 Sentence denotes The histological picture is consistent with scleroderma.
T16 1757-1813 Sentence denotes The histological picture is consistent with scleroderma.
T17 1814-1961 Sentence denotes Capillaroscopy changes, antinuclear antibodies (ANA), sclerodactyly, and Raynaud phenomenon suggest the diagnosis of systemic scleroderma (SS) (4).
T17 1814-1961 Sentence denotes Capillaroscopy changes, antinuclear antibodies (ANA), sclerodactyly, and Raynaud phenomenon suggest the diagnosis of systemic scleroderma (SS) (4).
T18 1962-2021 Sentence denotes Our patients did not fulfill enough of the criteria for SS.
T18 1962-2021 Sentence denotes Our patients did not fulfill enough of the criteria for SS.
T19 2022-2134 Sentence denotes Both diffuse and localized scleroderma was seen in 3 patients and generalized localized scleroderma in one case.
T19 2022-2134 Sentence denotes Both diffuse and localized scleroderma was seen in 3 patients and generalized localized scleroderma in one case.
T20 2135-2256 Sentence denotes All patients had a histological picture consistent with scleroderma, negative ANA and ENA antibodies (Table 1, Figure 1).
T20 2135-2256 Sentence denotes All patients had a histological picture consistent with scleroderma, negative ANA and ENA antibodies (Table 1, Figure 1).
T21 2257-2391 Sentence denotes A 66-year-old woman presented with a 10 months history of sclerodermatous plaques on her neck, trunk, and upper and lower extremities.
T21 2257-2391 Sentence denotes A 66-year-old woman presented with a 10 months history of sclerodermatous plaques on her neck, trunk, and upper and lower extremities.
T22 2392-2451 Sentence denotes The skin on her breasts and cheeks was diffusely indurated.
T22 2392-2451 Sentence denotes The skin on her breasts and cheeks was diffusely indurated.
T23 2452-2731 Sentence denotes Examination showed thrombocytopenia, elevated transaminases, Cancer antigen 19-9 (Ca 19-9), thyroid stimulating hormone (TSH), and anti-thyroid peroxidase antibodies, dysmotility of the lower part of esophagus, hepatosplenomegaly, cholecystolithiasis, and benign polyps of colon.
T23 2452-2731 Sentence denotes Examination showed thrombocytopenia, elevated transaminases, Cancer antigen 19-9 (Ca 19-9), thyroid stimulating hormone (TSH), and anti-thyroid peroxidase antibodies, dysmotility of the lower part of esophagus, hepatosplenomegaly, cholecystolithiasis, and benign polyps of colon.
T24 2732-2800 Sentence denotes She was given prednisone 40 mg/day but did not return for follow up.
T24 2732-2800 Sentence denotes She was given prednisone 40 mg/day but did not return for follow up.
T25 2801-2916 Sentence denotes After 6 months she was diagnosed with cholangiogenic carcinoma with metastatic disease and died shortly afterwards.
T25 2801-2916 Sentence denotes After 6 months she was diagnosed with cholangiogenic carcinoma with metastatic disease and died shortly afterwards.
T26 2917-2992 Sentence denotes A 74-year-old woman had localized scleroderma on the trunk for three years.
T26 2917-2992 Sentence denotes A 74-year-old woman had localized scleroderma on the trunk for three years.
T27 2993-3090 Sentence denotes She was treated with procaine penicillin for positive borrelia Immunoglobulin M (IgM) antibodies.
T27 2993-3090 Sentence denotes She was treated with procaine penicillin for positive borrelia Immunoglobulin M (IgM) antibodies.
T28 3091-3288 Sentence denotes Her condition worsened suddenly with confluent scleroderma plaques on her trunk, extremities, and genital region, and vasoneurosis on her lower extremities; she was started on prednisone 35 mg/day.
T28 3091-3288 Sentence denotes Her condition worsened suddenly with confluent scleroderma plaques on her trunk, extremities, and genital region, and vasoneurosis on her lower extremities; she was started on prednisone 35 mg/day.
T29 3289-3329 Sentence denotes Examination revealed endometrial cancer.
T29 3289-3329 Sentence denotes Examination revealed endometrial cancer.
T30 3330-3419 Sentence denotes The patient underwent a hysterectomy, adnexectomy, and radiotherapy with curative effect.
T30 3330-3419 Sentence denotes The patient underwent a hysterectomy, adnexectomy, and radiotherapy with curative effect.
T31 3420-3525 Sentence denotes Scleroderma patches softened with residual hyperpigmentation, and prednisone was stopped two years later.
T31 3420-3525 Sentence denotes Scleroderma patches softened with residual hyperpigmentation, and prednisone was stopped two years later.
T32 3526-3697 Sentence denotes A 80-year-old man had a month-long history of diffuse thickening and toughening of the skin on the forearms and lower legs and scleroderma patches on the thighs and shins.
T32 3526-3697 Sentence denotes A 80-year-old man had a month-long history of diffuse thickening and toughening of the skin on the forearms and lower legs and scleroderma patches on the thighs and shins.
T33 3698-3824 Sentence denotes Examination revealed prostate adenocarcinoma, and therapy with antiandrogen bicalutamide and prednisone 15 mg/day was started.
T33 3698-3824 Sentence denotes Examination revealed prostate adenocarcinoma, and therapy with antiandrogen bicalutamide and prednisone 15 mg/day was started.
T34 3825-3978 Sentence denotes Two years after the diagnosis he continues with bicalutamide treatment, prednisone 5 mg q.a.d. and has residual toughening of the skin on his lower legs.
T34 3825-3978 Sentence denotes Two years after the diagnosis he continues with bicalutamide treatment, prednisone 5 mg q.a.d. and has residual toughening of the skin on his lower legs.
T35 3979-4125 Sentence denotes A 62-year-old woman with seronegative rheumatoid arthritis presented with diffusely tough skin on her extremities and trunk, present for 2 months.
T35 3979-4125 Sentence denotes A 62-year-old woman with seronegative rheumatoid arthritis presented with diffusely tough skin on her extremities and trunk, present for 2 months.
T36 4126-4291 Sentence denotes Examination revealed cervicitis with a benign endometric polyp, cholecystolithiasis, borderline pulmonary hypertension, and a hormonally inactive suprarenal adenoma.
T36 4126-4291 Sentence denotes Examination revealed cervicitis with a benign endometric polyp, cholecystolithiasis, borderline pulmonary hypertension, and a hormonally inactive suprarenal adenoma.
T37 4292-4357 Sentence denotes She was given prednisone 40 mg/day and penicillamine with effect.
T37 4292-4357 Sentence denotes She was given prednisone 40 mg/day and penicillamine with effect.
T38 4358-4477 Sentence denotes In the 3rd year of therapy she has residual induration of her lower legs and a scleroderma plaque in the lumbar region.
T38 4358-4477 Sentence denotes In the 3rd year of therapy she has residual induration of her lower legs and a scleroderma plaque in the lumbar region.
T39 4478-4522 Sentence denotes She is monitored for her suprarenal adenoma.
T39 4478-4522 Sentence denotes She is monitored for her suprarenal adenoma.
T40 4523-4742 Sentence denotes Two patients had scleroderma at the same time as a malignant tumor; in one patient the localized scleroderma worsened rapidly at the time of the tumor diagnosis, and in one patient a clinically silent adenoma was found.
T40 4523-4742 Sentence denotes Two patients had scleroderma at the same time as a malignant tumor; in one patient the localized scleroderma worsened rapidly at the time of the tumor diagnosis, and in one patient a clinically silent adenoma was found.
T41 4743-4837 Sentence denotes Adrenal tissue can secrete molecules such as serotonine or bFGF involved in fibroplasia (3,6).
T41 4743-4837 Sentence denotes Adrenal tissue can secrete molecules such as serotonine or bFGF involved in fibroplasia (3,6).
T42 4838-5042 Sentence denotes One patient died of a metastatic disease, two patients after the successful treatment of the tumor, and the patient with suprarenal adenoma experienced softening of the skin and regression of scleroderma.
T42 4838-5042 Sentence denotes One patient died of a metastatic disease, two patients after the successful treatment of the tumor, and the patient with suprarenal adenoma experienced softening of the skin and regression of scleroderma.
T43 5043-5192 Sentence denotes Although paraneoplastic scleroderma is often classified as a pseudoscleroderma, we regard neoplasia as a distinct triggering impulse for scleroderma.
T43 5043-5192 Sentence denotes Although paraneoplastic scleroderma is often classified as a pseudoscleroderma, we regard neoplasia as a distinct triggering impulse for scleroderma.
T44 5193-5311 Sentence denotes Recently, an association between RNA polymerase I/III antibodies in systemic scleroderma and cancer was suggested (8).
T44 5193-5311 Sentence denotes Recently, an association between RNA polymerase I/III antibodies in systemic scleroderma and cancer was suggested (8).
T45 5312-5386 Sentence denotes Such studies may confirm the true link between scleroderma and malignancy.
T45 5312-5386 Sentence denotes Such studies may confirm the true link between scleroderma and malignancy.
T46 5387-5544 Sentence denotes These patients are characterized by older age, sudden onset, diffuse thickening of the skin, and/or generalized morphea with a concurrent neoplastic process.
T46 5387-5544 Sentence denotes These patients are characterized by older age, sudden onset, diffuse thickening of the skin, and/or generalized morphea with a concurrent neoplastic process.
T47 5545-5611 Sentence denotes In the case of a successful tumor treatment, skin changes regress.
T47 5545-5611 Sentence denotes In the case of a successful tumor treatment, skin changes regress.