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PubMed:26791145 JSONTXT 8 Projects

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Id Subject Object Predicate Lexical cue
T1 0-91 Sentence denotes Cost of surviving sepsis: a novel model of recovery from sepsis in Drosophila melanogaster.
T1 0-91 Sentence denotes Cost of surviving sepsis: a novel model of recovery from sepsis in Drosophila melanogaster.
T2 92-103 Sentence denotes BACKGROUND:
T2 92-103 Sentence denotes BACKGROUND:
T3 104-253 Sentence denotes Multiple organ failure, wasting, increased morbidity, and mortality following acute illness complicates the health span of patients surviving sepsis.
T3 104-253 Sentence denotes Multiple organ failure, wasting, increased morbidity, and mortality following acute illness complicates the health span of patients surviving sepsis.
T4 254-429 Sentence denotes Persistent inflammation has been implicated, and it is proposed that insulin signaling contributes to persistent inflammatory signaling during the recovery phase after sepsis.
T4 254-429 Sentence denotes Persistent inflammation has been implicated, and it is proposed that insulin signaling contributes to persistent inflammatory signaling during the recovery phase after sepsis.
T5 430-507 Sentence denotes However, mechanisms are unknown and suitable pre-clinical models are lacking.
T5 430-507 Sentence denotes However, mechanisms are unknown and suitable pre-clinical models are lacking.
T6 508-745 Sentence denotes We therefore developed a novel Drosophila melanogaster model of sepsis to recapitulate the clinical course of sepsis, explored inflammation over time, and its relation to impaired mobility, metabolic disturbance, and changes in lifespan.
T6 508-745 Sentence denotes We therefore developed a novel Drosophila melanogaster model of sepsis to recapitulate the clinical course of sepsis, explored inflammation over time, and its relation to impaired mobility, metabolic disturbance, and changes in lifespan.
T7 746-754 Sentence denotes METHODS:
T7 746-754 Sentence denotes METHODS:
T8 755-907 Sentence denotes We used wild-type (WT), Drosomycin-green fluorescent protein (GFP), and NF-κB-luc reporter male Drosophila melanogaster 4-5 days of age (unmanipulated).
T8 755-907 Sentence denotes We used wild-type (WT), Drosomycin-green fluorescent protein (GFP), and NF-κB-luc reporter male Drosophila melanogaster 4-5 days of age (unmanipulated).
T9 908-1026 Sentence denotes We infected Drosophila with Staphylococcus aureus (infected without treatment) or pricked with aseptic needles (sham).
T9 908-1026 Sentence denotes We infected Drosophila with Staphylococcus aureus (infected without treatment) or pricked with aseptic needles (sham).
T10 1027-1127 Sentence denotes Subsets of insects were treated with oral linezolid after the infection (infected with antibiotics).
T10 1027-1127 Sentence denotes Subsets of insects were treated with oral linezolid after the infection (infected with antibiotics).
T11 1128-1282 Sentence denotes We assessed rapid iterative negative geotaxis (RING) in all the groups as a surrogate for neuromuscular functional outcome up to 96 h following infection.
T11 1128-1282 Sentence denotes We assessed rapid iterative negative geotaxis (RING) in all the groups as a surrogate for neuromuscular functional outcome up to 96 h following infection.
T12 1283-1460 Sentence denotes We harvested the flies over the 7-day course to evaluate bacterial burden, inflammatory and metabolic pathway gene expression patterns, NF-κB translation, and metabolic reserve.
T12 1283-1460 Sentence denotes We harvested the flies over the 7-day course to evaluate bacterial burden, inflammatory and metabolic pathway gene expression patterns, NF-κB translation, and metabolic reserve.
T13 1461-1504 Sentence denotes We also followed the lifespan of the flies.
T13 1461-1504 Sentence denotes We also followed the lifespan of the flies.
T14 1505-1513 Sentence denotes RESULTS:
T14 1505-1513 Sentence denotes RESULTS:
T15 1514-1702 Sentence denotes Our results showed that when treated with antibiotics, flies had improved survival compared to infected without treatment flies in the early phase of sepsis up to 1 week (81 %, p = 0.001).
T15 1514-1702 Sentence denotes Our results showed that when treated with antibiotics, flies had improved survival compared to infected without treatment flies in the early phase of sepsis up to 1 week (81 %, p = 0.001).
T16 1703-1825 Sentence denotes However, the lifespan of infected with antibiotics flies was significantly shorter than that of sham controls (p = 0.001).
T16 1703-1825 Sentence denotes However, the lifespan of infected with antibiotics flies was significantly shorter than that of sham controls (p = 0.001).
T17 1826-2002 Sentence denotes Among infected with antibiotic sepsis survivors, we observed persistent elevation of NF-κB in the absence of any obvious infection as shown by culturing flies surviving sepsis.
T17 1826-2002 Sentence denotes Among infected with antibiotic sepsis survivors, we observed persistent elevation of NF-κB in the absence of any obvious infection as shown by culturing flies surviving sepsis.
T18 2003-2098 Sentence denotes In the same group, geotaxis had an early (18 h) and sustained decline compared to its baseline.
T18 2003-2098 Sentence denotes In the same group, geotaxis had an early (18 h) and sustained decline compared to its baseline.
T19 2099-2247 Sentence denotes Geotaxis in infected with antibiotics sepsis survivors was significantly lower than that in sham and age-matched unmanipulated flies at 18 and 48 h.
T19 2099-2247 Sentence denotes Geotaxis in infected with antibiotics sepsis survivors was significantly lower than that in sham and age-matched unmanipulated flies at 18 and 48 h.
T20 2248-2448 Sentence denotes Expression of antimicrobial peptides (AMP) remained significantly elevated over the course of 7 days after sepsis, especially drosomycin (5.7-fold, p = 0.0145) on day 7 compared to that of sham flies.
T20 2248-2448 Sentence denotes Expression of antimicrobial peptides (AMP) remained significantly elevated over the course of 7 days after sepsis, especially drosomycin (5.7-fold, p = 0.0145) on day 7 compared to that of sham flies.
T21 2449-2614 Sentence denotes Infected with antibiotics flies had a trend towards decreased Akt activation, yet their glucose stores were significantly lower than those of sham flies (p = 0.001).
T21 2449-2614 Sentence denotes Infected with antibiotics flies had a trend towards decreased Akt activation, yet their glucose stores were significantly lower than those of sham flies (p = 0.001).
T22 2615-2760 Sentence denotes Sepsis survivors had increased lactate levels and LDH activity by 1 week, whereas ATP and pyruvate content was similar to that of the sham group.
T22 2615-2760 Sentence denotes Sepsis survivors had increased lactate levels and LDH activity by 1 week, whereas ATP and pyruvate content was similar to that of the sham group.
T23 2761-2773 Sentence denotes CONCLUSIONS:
T23 2761-2773 Sentence denotes CONCLUSIONS:
T24 2774-2934 Sentence denotes In summary, our model mimics human survivors of sepsis with persistent inflammation, impaired motility, dysregulated glucose metabolism, and shortened lifespan.
T24 2774-2934 Sentence denotes In summary, our model mimics human survivors of sepsis with persistent inflammation, impaired motility, dysregulated glucose metabolism, and shortened lifespan.