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PubMed:25331954 JSONTXT 43 Projects

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Id Subject Object Predicate Lexical cue
T1 0-87 Sentence denotes Proteinase-activated receptor 2 (PAR2) decreases apoptosis in colonic epithelial cells.
T1 0-87 Sentence denotes Proteinase-activated receptor 2 (PAR2) decreases apoptosis in colonic epithelial cells.
T2 88-304 Sentence denotes Mucosal biopsies from inflamed colon of inflammatory bowel disease patients exhibit elevated epithelial apoptosis compared with those from healthy individuals, disrupting mucosal homeostasis and perpetuating disease.
T2 88-304 Sentence denotes Mucosal biopsies from inflamed colon of inflammatory bowel disease patients exhibit elevated epithelial apoptosis compared with those from healthy individuals, disrupting mucosal homeostasis and perpetuating disease.
T3 305-487 Sentence denotes Therapies that decrease intestinal epithelial apoptosis may, therefore, ameliorate inflammatory bowel disease, but treatments that specifically target apoptotic pathways are lacking.
T3 305-487 Sentence denotes Therapies that decrease intestinal epithelial apoptosis may, therefore, ameliorate inflammatory bowel disease, but treatments that specifically target apoptotic pathways are lacking.
T4 488-697 Sentence denotes Proteinase-activated receptor-2 (PAR2), a G protein-coupled receptor activated by trypsin-like serine proteinases, is expressed on intestinal epithelial cells and stimulates mitogenic pathways upon activation.
T4 488-697 Sentence denotes Proteinase-activated receptor-2 (PAR2), a G protein-coupled receptor activated by trypsin-like serine proteinases, is expressed on intestinal epithelial cells and stimulates mitogenic pathways upon activation.
T5 698-907 Sentence denotes We sought to determine whether PAR2 activation and signaling could rescue colonic epithelial (HT-29) cells from apoptosis induced by proapoptotic cytokines that are increased during inflammatory bowel disease.
T5 698-907 Sentence denotes We sought to determine whether PAR2 activation and signaling could rescue colonic epithelial (HT-29) cells from apoptosis induced by proapoptotic cytokines that are increased during inflammatory bowel disease.
T6 908-1152 Sentence denotes The PAR2 agonists 2-furoyl-LIGRLO (2f-LI), SLIGKV and trypsin all significantly reduced cleavage of caspase-3, -8, and -9, poly(ADP-ribose) polymerase, and the externalization of phosphatidylserine after treatment of cells with IFN-γ and TNF-α.
T6 908-1152 Sentence denotes The PAR2 agonists 2-furoyl-LIGRLO (2f-LI), SLIGKV and trypsin all significantly reduced cleavage of caspase-3, -8, and -9, poly(ADP-ribose) polymerase, and the externalization of phosphatidylserine after treatment of cells with IFN-γ and TNF-α.
T7 1153-1303 Sentence denotes Knockdown of PAR2 with siRNA eliminated the anti-apoptotic effect of 2f-LI and increased the sensitivity of HT-29 cells to cytokine-induced apoptosis.
T7 1153-1303 Sentence denotes Knockdown of PAR2 with siRNA eliminated the anti-apoptotic effect of 2f-LI and increased the sensitivity of HT-29 cells to cytokine-induced apoptosis.
T8 1304-1397 Sentence denotes Concurrent inhibition of both MEK1/2 and PI3K was necessary to inhibit PAR2-induced survival.
T8 1304-1397 Sentence denotes Concurrent inhibition of both MEK1/2 and PI3K was necessary to inhibit PAR2-induced survival.
T9 1398-1558 Sentence denotes 2f-LI was found to increase phosphorylation and inactivation of pro-apoptotic BAD at Ser(112) and Ser(136) by MEK1/2 and PI3K-dependent signaling, respectively.
T9 1398-1558 Sentence denotes 2f-LI was found to increase phosphorylation and inactivation of pro-apoptotic BAD at Ser(112) and Ser(136) by MEK1/2 and PI3K-dependent signaling, respectively.
T10 1559-1629 Sentence denotes PAR2 activation also increased the expression of anti-apoptotic MCL-1.
T10 1559-1629 Sentence denotes PAR2 activation also increased the expression of anti-apoptotic MCL-1.
T11 1630-1760 Sentence denotes Simultaneous knockdown of both BAD and MCL-1 had minimal effects on PAR2-induced survival, whereas single knockdown had no effect.
T11 1630-1760 Sentence denotes Simultaneous knockdown of both BAD and MCL-1 had minimal effects on PAR2-induced survival, whereas single knockdown had no effect.
T12 1761-1926 Sentence denotes We conclude that PAR2 activation reduces cytokine-induced epithelial apoptosis via concurrent stimulation of MEK1/2 and PI3K but little involvement of MCL-1 and BAD.
T12 1761-1926 Sentence denotes We conclude that PAR2 activation reduces cytokine-induced epithelial apoptosis via concurrent stimulation of MEK1/2 and PI3K but little involvement of MCL-1 and BAD.
T13 1927-2086 Sentence denotes Our findings represent a novel mechanism whereby serine proteinases facilitate epithelial cell survival and may be important in the context of colonic healing.
T13 1927-2086 Sentence denotes Our findings represent a novel mechanism whereby serine proteinases facilitate epithelial cell survival and may be important in the context of colonic healing.