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PubMed:23630968 JSONTXT 5 Projects

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Id Subject Object Predicate Lexical cue
T1 0-102 Sentence denotes Investigation of the function of Candida albicans Als3 by heterologous expression in Candida glabrata.
T1 0-102 Sentence denotes Investigation of the function of Candida albicans Als3 by heterologous expression in Candida glabrata.
T2 103-260 Sentence denotes During hematogenously disseminated infection, blood-borne Candida albicans invades the endothelial cell lining of the vasculature to invade the deep tissues.
T2 103-260 Sentence denotes During hematogenously disseminated infection, blood-borne Candida albicans invades the endothelial cell lining of the vasculature to invade the deep tissues.
T3 261-461 Sentence denotes Although the C. albicans Als3 invasin is critical for invasion and damage of endothelial cells in vitro, a C. albicans als3Δ/Δ mutant has normal virulence in the mouse model of disseminated infection.
T3 261-461 Sentence denotes Although the C. albicans Als3 invasin is critical for invasion and damage of endothelial cells in vitro, a C. albicans als3Δ/Δ mutant has normal virulence in the mouse model of disseminated infection.
T4 462-584 Sentence denotes We hypothesized that the contribution of Als3 to virulence is obscured by the presence of additional C. albicans invasins.
T4 462-584 Sentence denotes We hypothesized that the contribution of Als3 to virulence is obscured by the presence of additional C. albicans invasins.
T5 585-765 Sentence denotes To elucidate the in vivo function of Als3, we heterologously expressed C. albicans ALS3 in Candida glabrata, a yeast that lacks a close ALS3 ortholog and has low virulence in mice.
T5 585-765 Sentence denotes To elucidate the in vivo function of Als3, we heterologously expressed C. albicans ALS3 in Candida glabrata, a yeast that lacks a close ALS3 ortholog and has low virulence in mice.
T6 766-1039 Sentence denotes We found that following intravenous inoculation into mice, the ALS3-expressing strain preferentially trafficked to the brain, where it induced significantly elevated levels of myeloperoxidase, tumor necrosis factor, monocyte chemoattractant protein 1, and gamma interferon.
T6 766-1039 Sentence denotes We found that following intravenous inoculation into mice, the ALS3-expressing strain preferentially trafficked to the brain, where it induced significantly elevated levels of myeloperoxidase, tumor necrosis factor, monocyte chemoattractant protein 1, and gamma interferon.
T7 1040-1236 Sentence denotes Also, the ALS3-expressing strain had enhanced adherence to and invasion of human brain microvascular endothelial cells in vitro, demonstrating a potential mechanism for ALS3-mediated neurotropism.
T7 1040-1236 Sentence denotes Also, the ALS3-expressing strain had enhanced adherence to and invasion of human brain microvascular endothelial cells in vitro, demonstrating a potential mechanism for ALS3-mediated neurotropism.
T8 1237-1362 Sentence denotes In addition, upon initiation of infection, the ALS3-expressing strain had increased trafficking to the cortex of the kidneys.
T8 1237-1362 Sentence denotes In addition, upon initiation of infection, the ALS3-expressing strain had increased trafficking to the cortex of the kidneys.
T9 1363-1534 Sentence denotes With prolonged infection, this strain persisted in the kidneys at significantly higher levels than the control strain but did not induce an elevated inflammatory response.
T9 1363-1534 Sentence denotes With prolonged infection, this strain persisted in the kidneys at significantly higher levels than the control strain but did not induce an elevated inflammatory response.
T10 1535-1627 Sentence denotes Finally, the ALS3-expressing strain had increased resistance to neutrophil killing in vitro.
T10 1535-1627 Sentence denotes Finally, the ALS3-expressing strain had increased resistance to neutrophil killing in vitro.
T11 1628-1804 Sentence denotes These results indicate that during disseminated infection, Als3 mediates initial trafficking to the brain and renal cortex and contributes to fungal persistence in the kidneys.
T11 1628-1804 Sentence denotes These results indicate that during disseminated infection, Als3 mediates initial trafficking to the brain and renal cortex and contributes to fungal persistence in the kidneys.