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PubMed:21045008 JSONTXT 57 Projects

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Id Subject Object Predicate Lexical cue
T1 0-80 Sentence denotes Impact of mannose-binding lectin insufficiency on the course of cystic fibrosis:
T1 0-80 Sentence denotes Impact of mannose-binding lectin insufficiency on the course of cystic fibrosis:
T2 81-108 Sentence denotes A review and meta-analysis.
T2 81-108 Sentence denotes A review and meta-analysis.
T3 109-188 Sentence denotes Mannose-binding lectin (MBL) is an innate immune protein produced by the liver.
T3 109-188 Sentence denotes Mannose-binding lectin (MBL) is an innate immune protein produced by the liver.
T4 189-334 Sentence denotes MBL binds to glycoconjugates containing mannose, fucose or N-acetylglucosamine that are present in a wide variety of bacteria, viruses and fungi.
T4 189-334 Sentence denotes MBL binds to glycoconjugates containing mannose, fucose or N-acetylglucosamine that are present in a wide variety of bacteria, viruses and fungi.
T5 335-452 Sentence denotes Upon binding, MBL may active the lectin pathway of complement or directly opsonize organisms to enhance phagocytosis.
T5 335-452 Sentence denotes Upon binding, MBL may active the lectin pathway of complement or directly opsonize organisms to enhance phagocytosis.
T6 453-540 Sentence denotes MBL is primarily a serum protein but accumulates in the lung during acute inflammation.
T6 453-540 Sentence denotes MBL is primarily a serum protein but accumulates in the lung during acute inflammation.
T7 541-629 Sentence denotes Recent evidence suggests an important role for MBL in a variety of infectious disorders.
T7 541-629 Sentence denotes Recent evidence suggests an important role for MBL in a variety of infectious disorders.
T8 630-755 Sentence denotes Cystic fibrosis (CF) is a multisystem disease caused by mutations in the gene encoding the CF transmembrane regulator (CFTR).
T8 630-755 Sentence denotes Cystic fibrosis (CF) is a multisystem disease caused by mutations in the gene encoding the CF transmembrane regulator (CFTR).
T9 756-917 Sentence denotes The course of CF lung disease is highly variable even in patients with the same CFTR genotype, suggesting that other modulator genes are important for prognosis.
T9 756-917 Sentence denotes The course of CF lung disease is highly variable even in patients with the same CFTR genotype, suggesting that other modulator genes are important for prognosis.
T10 918-991 Sentence denotes MBL has been proposed as a possible modulator of clinical severity in CF.
T10 918-991 Sentence denotes MBL has been proposed as a possible modulator of clinical severity in CF.
T11 992-1360 Sentence denotes In this review and meta-analysis, we found that MBL2 genotypes associated with MBL insufficiency were associated with earlier acquisition of Pseudomonas aeruginosa (P < 0.0001), reduced pulmonary function among adult patients (P < 0.0001 for forced expiratory volume), and an increased rate of death or requirement for lung transplantation (odds ratio 3.69; P = 0.02).
T11 992-1360 Sentence denotes In this review and meta-analysis, we found that MBL2 genotypes associated with MBL insufficiency were associated with earlier acquisition of Pseudomonas aeruginosa (P < 0.0001), reduced pulmonary function among adult patients (P < 0.0001 for forced expiratory volume), and an increased rate of death or requirement for lung transplantation (odds ratio 3.69; P = 0.02).
T12 1361-1477 Sentence denotes The available evidence therefore suggests that MBL insufficiency is associated with the severity of CF lung disease.
T12 1361-1477 Sentence denotes The available evidence therefore suggests that MBL insufficiency is associated with the severity of CF lung disease.
T13 1478-1570 Sentence denotes The possible future prophylactic or therapeutic application of MBL replacement is discussed.
T13 1478-1570 Sentence denotes The possible future prophylactic or therapeutic application of MBL replacement is discussed.