Id |
Subject |
Object |
Predicate |
Lexical cue |
T1 |
0-80 |
Sentence |
denotes |
Impact of mannose-binding lectin insufficiency on the course of cystic fibrosis: |
T1 |
0-80 |
Sentence |
denotes |
Impact of mannose-binding lectin insufficiency on the course of cystic fibrosis: |
T2 |
81-108 |
Sentence |
denotes |
A review and meta-analysis. |
T2 |
81-108 |
Sentence |
denotes |
A review and meta-analysis. |
T3 |
109-188 |
Sentence |
denotes |
Mannose-binding lectin (MBL) is an innate immune protein produced by the liver. |
T3 |
109-188 |
Sentence |
denotes |
Mannose-binding lectin (MBL) is an innate immune protein produced by the liver. |
T4 |
189-334 |
Sentence |
denotes |
MBL binds to glycoconjugates containing mannose, fucose or N-acetylglucosamine that are present in a wide variety of bacteria, viruses and fungi. |
T4 |
189-334 |
Sentence |
denotes |
MBL binds to glycoconjugates containing mannose, fucose or N-acetylglucosamine that are present in a wide variety of bacteria, viruses and fungi. |
T5 |
335-452 |
Sentence |
denotes |
Upon binding, MBL may active the lectin pathway of complement or directly opsonize organisms to enhance phagocytosis. |
T5 |
335-452 |
Sentence |
denotes |
Upon binding, MBL may active the lectin pathway of complement or directly opsonize organisms to enhance phagocytosis. |
T6 |
453-540 |
Sentence |
denotes |
MBL is primarily a serum protein but accumulates in the lung during acute inflammation. |
T6 |
453-540 |
Sentence |
denotes |
MBL is primarily a serum protein but accumulates in the lung during acute inflammation. |
T7 |
541-629 |
Sentence |
denotes |
Recent evidence suggests an important role for MBL in a variety of infectious disorders. |
T7 |
541-629 |
Sentence |
denotes |
Recent evidence suggests an important role for MBL in a variety of infectious disorders. |
T8 |
630-755 |
Sentence |
denotes |
Cystic fibrosis (CF) is a multisystem disease caused by mutations in the gene encoding the CF transmembrane regulator (CFTR). |
T8 |
630-755 |
Sentence |
denotes |
Cystic fibrosis (CF) is a multisystem disease caused by mutations in the gene encoding the CF transmembrane regulator (CFTR). |
T9 |
756-917 |
Sentence |
denotes |
The course of CF lung disease is highly variable even in patients with the same CFTR genotype, suggesting that other modulator genes are important for prognosis. |
T9 |
756-917 |
Sentence |
denotes |
The course of CF lung disease is highly variable even in patients with the same CFTR genotype, suggesting that other modulator genes are important for prognosis. |
T10 |
918-991 |
Sentence |
denotes |
MBL has been proposed as a possible modulator of clinical severity in CF. |
T10 |
918-991 |
Sentence |
denotes |
MBL has been proposed as a possible modulator of clinical severity in CF. |
T11 |
992-1360 |
Sentence |
denotes |
In this review and meta-analysis, we found that MBL2 genotypes associated with MBL insufficiency were associated with earlier acquisition of Pseudomonas aeruginosa (P < 0.0001), reduced pulmonary function among adult patients (P < 0.0001 for forced expiratory volume), and an increased rate of death or requirement for lung transplantation (odds ratio 3.69; P = 0.02). |
T11 |
992-1360 |
Sentence |
denotes |
In this review and meta-analysis, we found that MBL2 genotypes associated with MBL insufficiency were associated with earlier acquisition of Pseudomonas aeruginosa (P < 0.0001), reduced pulmonary function among adult patients (P < 0.0001 for forced expiratory volume), and an increased rate of death or requirement for lung transplantation (odds ratio 3.69; P = 0.02). |
T12 |
1361-1477 |
Sentence |
denotes |
The available evidence therefore suggests that MBL insufficiency is associated with the severity of CF lung disease. |
T12 |
1361-1477 |
Sentence |
denotes |
The available evidence therefore suggests that MBL insufficiency is associated with the severity of CF lung disease. |
T13 |
1478-1570 |
Sentence |
denotes |
The possible future prophylactic or therapeutic application of MBL replacement is discussed. |
T13 |
1478-1570 |
Sentence |
denotes |
The possible future prophylactic or therapeutic application of MBL replacement is discussed. |