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PubMed:18408466 JSONTXT 8 Projects

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Id Subject Object Predicate Lexical cue
T1 0-98 Sentence denotes Genetics of biliary tract diseases: new insights into gallstone disease and biliary tract cancers.
T1 0-98 Sentence denotes Genetics of biliary tract diseases: new insights into gallstone disease and biliary tract cancers.
T2 99-117 Sentence denotes PURPOSE OF REVIEW:
T2 99-117 Sentence denotes PURPOSE OF REVIEW:
T3 118-217 Sentence denotes Chronic biliary diseases are due to complex interactions between environmental and genetic factors.
T3 118-217 Sentence denotes Chronic biliary diseases are due to complex interactions between environmental and genetic factors.
T4 218-406 Sentence denotes Here we summarize the current knowledge of genetic factors that contribute to common biliary diseases, focusing on gallstones and carcinogenesis, and review the recent association studies.
T4 218-406 Sentence denotes Here we summarize the current knowledge of genetic factors that contribute to common biliary diseases, focusing on gallstones and carcinogenesis, and review the recent association studies.
T5 407-423 Sentence denotes RECENT FINDINGS:
T5 407-423 Sentence denotes RECENT FINDINGS:
T6 424-518 Sentence denotes Since most studies were based on small sample sizes, replication of the findings is mandatory.
T6 424-518 Sentence denotes Since most studies were based on small sample sizes, replication of the findings is mandatory.
T7 519-752 Sentence denotes Recently a large twin study confirmed a genetic predisposition to gallstones and a genome-wide association scan identified the hepatocanalicular cholesterol transporter ABCG8 as the common susceptibility factor for gallstone disease.
T7 519-752 Sentence denotes Recently a large twin study confirmed a genetic predisposition to gallstones and a genome-wide association scan identified the hepatocanalicular cholesterol transporter ABCG8 as the common susceptibility factor for gallstone disease.
T8 753-956 Sentence denotes Genetic studies in patients with cholangiocarcinoma indicate that genes controlling the metabolism and transport of xenobiotics or modulating chronic inflammation may determine individual susceptibility.
T8 753-956 Sentence denotes Genetic studies in patients with cholangiocarcinoma indicate that genes controlling the metabolism and transport of xenobiotics or modulating chronic inflammation may determine individual susceptibility.
T9 957-965 Sentence denotes SUMMARY:
T9 957-965 Sentence denotes SUMMARY:
T10 966-1116 Sentence denotes Genetic studies have identified the first susceptibility factors for gallstones and biliary tract cancers, but most results have yet to be replicated.
T10 966-1116 Sentence denotes Genetic studies have identified the first susceptibility factors for gallstones and biliary tract cancers, but most results have yet to be replicated.
T11 1117-1265 Sentence denotes In the future, genome-wide studies in different populations are likely to identify the entire set of genes contributing to chronic biliary diseases.
T11 1117-1265 Sentence denotes In the future, genome-wide studies in different populations are likely to identify the entire set of genes contributing to chronic biliary diseases.
T12 1266-1565 Sentence denotes Since the disease phenotypes result from the manifestation of susceptibility factors under the influence of environmental triggers, the discovery of these genes will open avenues to control environmental challenges and lead to novel strategies for risk assessment ('gene signatures') and prevention.
T12 1266-1565 Sentence denotes Since the disease phenotypes result from the manifestation of susceptibility factors under the influence of environmental triggers, the discovery of these genes will open avenues to control environmental challenges and lead to novel strategies for risk assessment ('gene signatures') and prevention.