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PubMed:10790428 JSONTXT 5 Projects

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Id Subject Object Predicate Lexical cue
T1 0-159 Sentence denotes The serpin proteinase inhibitor 9 is an endogenous inhibitor of interleukin 1beta-converting enzyme (caspase-1) activity in human vascular smooth muscle cells.
T1 0-159 Sentence denotes The serpin proteinase inhibitor 9 is an endogenous inhibitor of interleukin 1beta-converting enzyme (caspase-1) activity in human vascular smooth muscle cells.
T2 160-374 Sentence denotes Interleukin-1beta-converting enzyme (ICE, caspase-1) regulates key steps in inflammation and immunity, by activating the proinflammatory cytokines interleukin (IL-)1beta and IL-18, or mediating apoptotic processes.
T2 160-374 Sentence denotes Interleukin-1beta-converting enzyme (ICE, caspase-1) regulates key steps in inflammation and immunity, by activating the proinflammatory cytokines interleukin (IL-)1beta and IL-18, or mediating apoptotic processes.
T3 375-547 Sentence denotes We recently provided evidence for the regulation of caspase-1 activity via an endogenous inhibitor expressed by human vascular smooth muscle cells (SMCs) (Schönbeck, U., M.
T3 375-547 Sentence denotes We recently provided evidence for the regulation of caspase-1 activity via an endogenous inhibitor expressed by human vascular smooth muscle cells (SMCs) (Schönbeck, U., M.
T4 548-560 Sentence denotes Herzberg, A.
T4 548-560 Sentence denotes Herzberg, A.
T5 561-573 Sentence denotes Petersen, C.
T5 561-573 Sentence denotes Petersen, C.
T6 574-588 Sentence denotes Wohlenberg, J.
T6 574-588 Sentence denotes Wohlenberg, J.
T7 589-602 Sentence denotes Gerdes, H.-D.
T7 589-602 Sentence denotes Gerdes, H.-D.
T8 603-615 Sentence denotes Flad, and H.
T8 603-615 Sentence denotes Flad, and H.
T9 616-624 Sentence denotes Loppnow.
T9 616-624 Sentence denotes Loppnow.
T10 625-630 Sentence denotes 1997.
T10 625-630 Sentence denotes 1997.
T11 631-633 Sentence denotes J.
T11 631-633 Sentence denotes J.
T12 634-638 Sentence denotes Exp.
T12 634-638 Sentence denotes Exp.
T13 639-643 Sentence denotes Med.
T13 639-643 Sentence denotes Med.
T14 644-659 Sentence denotes 185:1287-1294).
T14 644-659 Sentence denotes 185:1287-1294).
T15 660-740 Sentence denotes However, the molecular identity of this endogenous inhibitor remained undefined.
T15 660-740 Sentence denotes However, the molecular identity of this endogenous inhibitor remained undefined.
T16 741-968 Sentence denotes We report here that the serine proteinase inhibitor (serpin) PI-9 accounts for the endogenous caspase-1 inhibitory activity in human SMCs and prevents processing of the enzyme's natural substrates, IL-1beta and IL-18 precursor.
T16 741-968 Sentence denotes We report here that the serine proteinase inhibitor (serpin) PI-9 accounts for the endogenous caspase-1 inhibitory activity in human SMCs and prevents processing of the enzyme's natural substrates, IL-1beta and IL-18 precursor.
T17 969-1135 Sentence denotes Treatment of SMC lysates with anti-PI-9 antibody abrogated the caspase-1 inhibitory activity and coprecipitated the enzyme, demonstrating protein-protein interaction.
T17 969-1135 Sentence denotes Treatment of SMC lysates with anti-PI-9 antibody abrogated the caspase-1 inhibitory activity and coprecipitated the enzyme, demonstrating protein-protein interaction.
T18 1136-1248 Sentence denotes Furthermore, PI-9 antisense oligonucleotides coordinately reduced PI-9 expression and promoted IL-1beta release.
T18 1136-1248 Sentence denotes Furthermore, PI-9 antisense oligonucleotides coordinately reduced PI-9 expression and promoted IL-1beta release.
T19 1249-1451 Sentence denotes Since SMCs comprise the majority of cells in the vascular wall, and because IL-1 is implicated in atherogenesis, we tested the biological validity of our in vitro findings within human atheroma in situ.
T19 1249-1451 Sentence denotes Since SMCs comprise the majority of cells in the vascular wall, and because IL-1 is implicated in atherogenesis, we tested the biological validity of our in vitro findings within human atheroma in situ.
T20 1452-1534 Sentence denotes The unaffected arterial wall contains abundant and homogeneously distributed PI-9.
T20 1452-1534 Sentence denotes The unaffected arterial wall contains abundant and homogeneously distributed PI-9.
T21 1535-1748 Sentence denotes In human atherosclerotic lesions, however, PI-9 expression correlated inversely with immunoreactive IL-1beta, supporting a potential role of the endogenous caspase-1 inhibitor in this chronic inflammatory disease.
T21 1535-1748 Sentence denotes In human atherosclerotic lesions, however, PI-9 expression correlated inversely with immunoreactive IL-1beta, supporting a potential role of the endogenous caspase-1 inhibitor in this chronic inflammatory disease.
T22 1749-2005 Sentence denotes Thus, our results provide new insights into the regulation of this enzyme involved in immune and inflammatory processes of chronic inflammatory diseases, and point to an endogenous antiinflammatory action of PI-9, dysregulated in a prevalent human disease.
T22 1749-2005 Sentence denotes Thus, our results provide new insights into the regulation of this enzyme involved in immune and inflammatory processes of chronic inflammatory diseases, and point to an endogenous antiinflammatory action of PI-9, dysregulated in a prevalent human disease.