PubMed:11776599 JSONTXT 2 Projects

[The study of nitric oxide synthase in ovary tumor]. OBJECTIVE: To study the activity of nitric oxide synthase (NOS) in ovarian tumors. METHODS: Spectrophotometry was used to examine NOS activity and NADPH-diaphorase histochemistry to identify its localization. RESULTS: The activity of NOS was significantly higher in malignant than in normal ovarian tissue and benign ovarian tumors (P < 0.01). There was negative correlation between NOS activity and tumor cell differentiation. NOS reaction product was mainly located in cancer cells, and was negative in the interstitial tissue. Furthermore, NOS was mostly located in membrane and cytoplasm of the cancer cell. CONCLUSION: Increase in nitric oxide synthase activity might be related to the growth and malignant behavior of ovarian cancer.