PubMed:11601039 JSONTXT

[Investigation of serum immunosuppresive acidic protein levels in gynecological tumor]. OBJECTIVE: To study the clinical significance for measureing serum immunosuppresive acidic protein (IAP) levels to diagnoze and follow up survey patients with the gynecological tumor. METHODS: Serum IAP levels were determined by IAP-single radial immunodiffusion test in 235 patients with gynecological tumor, 38 patients had benign ovary tumor, 41 were malignant ovary tumor, 66 hysteromyoma, 34 cervical carcinoma, 16 endometrial carcinoma, 27 received chemotherapy, and 13 had tumor recurrence. The control group consisted of 50 health women. RESULTS: The serum IAP level was (889 +/- 208) mg/L in malignant ovary tumor, and higher than that of the health women and benign ovary tumor, (P < 0.01). In patients with cervical carcinoma and endometrial carcinoma, the IAP level was (741 +/- 213) and (763 +/- 209) mg/L respectively, and higher than that of the health women and benign ovary tumor (P < 0.01). After chemotherapy, the serum IAP level of malignant ovary tumor was decreased. In patients with recurrence of ovary tumor, the IAP levels was increased to compare with the health women (P < 0.01), the incidence of the abnormal value was 100%. CONCLUSION: Detecting IAP level of the gynecological tumor may be an auxiliary index for monitoring gynecological tumor and identifying whether it is benign or malignant.