CORD-19:2cf45a5a4224dbf38d537eace1f6d49327e3487d JSONTXT 8 Projects

Supplementary Information 7: Vector-borne Disease Screening -General Principles Diagnostic testing Abstract does not distinguish between previous exposure and active infection. Combining PCR with serological testing enhances sensitivity. 6, 13, 14 Repeat testing, including repeating PCR on the same or additional samples, and pairwise serological testing to demonstrate a four-fold change between acute and convalescent titers, is also necessary to document infection in many cases. [6] [7] [8] [9] 13, 14 Although the distribution of vector-borne disease tends to follow its vectors, it is important to consider that the geographic distribution of many tick vectors and their associated pathogens is rapidly expanding. 15